Escin, found in Aesculus hippocastanum, stabilizes the blood-brain barrier to mitigate hemorrhagic transformation (HT) caused by recombinant tissue plasminogen activator (rt-PA). Important for safer use of rt-PA in clinical applications.
Scientists developed a method to separate and analyze carboxylated phytocannabinoids, their derivatives, and investigated chiral analysis and racemization parameters. It aids in understanding different Cannabis varieties.
Scientists investigated why the effectiveness of dietary nitrate supplementation in reducing blood pressure in pregnant women varies. They explored differences in oral microbiota profiles and nitrate-reducing capacity, aiming to understand the reasons behind individual variations in blood pressure response to nitrate supplementation.
Researchers aimed to understand the mechanisms and effective treatments for heart failure (HF), a major cause of death and clinical problem. The study highlights the need for an urgently developed strategy to combat HF.
An aged black garlic extract with low doses of SAC lowers blood pressure in Grade I hypertensive individuals on medication. It increases nitric oxide and antioxidant capacity, reduces uric acid levels and ACE activity, without affecting inflammation or endothelial function.
Various bioactive metabolites found in herbs such as Rosmarinus officinalis and Punica granatum have shown impressive angiotensin converting enzyme (ACE) inhibitory activity. These natural ACE inhibitors could be a potential treatment for hypertension, respiratory distress syndrome, and chronic kidney diseases, but more clinical trials are needed.
Solasonine (SS), the main ingredient in Solanum nigrum L., shows neuroprotective effects in vitro and in vivo models of cerebral ischemia/reperfusion injury (CIRI). It reduces inflammation, oxidative stress, and apoptosis in neurons, and improves neurological outcomes in rats. Mechanistically, it targets the TLR4/MyD88/NF-κB and AMPK/Nrf2/HO-1 pathways.
Researchers used network pharmacology and docking analysis to explore the potential of Arjuna in treating congestive cardiac failure (CCF). They identified several active compounds in Arjuna that target specific genes and signaling pathways, suggesting its potential as a preventive treatment for CCF.