Cardiology Studies

Pharmacodynamics and mechanism of Erigeron breviscapus granules in the treatment of ischemic stroke in mice by regulating sphingolipid metabolism based on metabolomics.

They studied how Erigeron breviscapus (EB) granules treat ischemic stroke (IS) by examining its metabolic effects. Understanding the mechanism can lead to better treatment options for IS.

Liu C et al (2024).
J Pharm Biomed Anal.
PubMed:
38422673

In Vivo Diuretic Activity and Anti-Hypertensive Potential of Hibiscus sabdariffa Extract by Inhibition of Angiotensin-Converting Enzyme and Hypertension Precursor Enzymes.

The study found that extracts from the calyx of roselle have potential anti-hypertensive effects by inhibiting various enzymes and showing diuretic activity. This suggests roselle could be a source of beneficial compounds for hypertension treatment.

Sanou A et al (2024).
Foods.
PubMed:
38397511

Network pharmacology and experimental validation to investigate the mechanism of Nao-Ling-Su capsule in the treatment of ischemia/reperfusion-induced acute kidney injury.

NLSC, a traditional herbal capsule, may have potential in treating acute kidney injury. Its ingredients have brain-strengthening and kidney-protecting effects, showing promise in clinical use.

Lin Y et al (2024).
J Ethnopharmacol.
PubMed:
38395179

Baicalein ameliorated obesity-induced cardiac dysfunction by regulating the mitochondrial unfolded protein response through NRF2 signaling.

Baicalein from Scutellaria baicalensis roots protects against obesity-induced heart damage by activating the mitochondrial unfolded protein response. Important for treating metabolic and cardiovascular diseases.

Guo L et al (2024).
Phytomedicine.
PubMed:
38394729

Herbal medicines provide regulation against iron overload in cardiovascular diseases: Informing future applications.

Scientists studied the impact of iron levels on cardiovascular diseases and found that iron overload can worsen conditions like cardiomyopathy and atherosclerosis. They are also researching the use of herbal medicines to regulate iron levels and potentially treat these diseases.

Liu J et al (2024).
J Ethnopharmacol.
PubMed:
38387684

Targeted arginine metabolomics combined with metagenomics revealed the potential mechanism of Pueraria lobata extract in treating myocardial infarction.

Researchers studied the therapeutic effects of Pueraria lobata water extract for treating myocardial infarction in rats. They found that the extract reduced cardiac injury, improved amino acid levels, and restored intestinal flora balance. This study provides new insights into the potential of Pueraria lobata in heart disease treatment.

Yi B et al (2024).
J Chromatogr A.
PubMed:
38387153

Exosomes derived from Baicalin-pretreated bone mesenchymal stem cells improve Th17/Treg imbalance after hepatic ischemia-reperfusion via FGF21 and the JAK2/STAT3 pathway.

Baicalin-preteated BMSC-derived exosomes reduce hepatic I/R injury by suppressing inflammation, improving cell balance, and inducing FGF21 expression. Baicalin enhances therapeutic potential of exosomes for liver damage.

Zhang B et al (2024).
IUBMB Life.
PubMed:
38380586

Integrating serum pharmacochemistry and network pharmacology to explore the molecular mechanisms of Acanthopanax senticosus (Rupr. & Maxim.) Harms on attenuating doxorubicin-induced myocardial injury.

Acanthopanax, or Siberian ginseng, may help reduce the cardiotoxicity of chemotherapeutic drug doxorubicin, potentially enhancing its anticancer effects. This could lead to safer and more effective cancer treatments.

Zhang X et al (2024).
J Ethnopharmacol.
PubMed:
38380572