Watermelon and L-Citrulline in Cardio-Metabolic Health: Review of the Evidence 2000-2020.

Burton-Freeman B et al (2021).

Curr Atheroscler Rep.

DOI:

10.1007/s11883-021-00978-5

PubMed:

34894302

Exploring the Therapeutic Mechanisms of Huzhang-Shanzha Herb Pair against Coronary Heart Disease by Network Pharmacology and Molecular Docking.

Li D et al (2021).

Evid Based Complement Alternat Med.

DOI:

10.1155/2021/5569666

PubMed:

34887932

A functional polysaccharide from Eriobotrya japonica relieves myocardial ischemia injury via anti-oxidative and anti-inflammatory effects.

Huang X et al (2022).

Food Funct.

DOI:

10.1039/d1fo03208a

PubMed:

34878451

Potentilla reptans L. postconditioning protects reperfusion injury via the RISK/SAFE pathways in an isolated rat heart.

Enayati A et al (2021).

BMC Complement Med Ther.

DOI:

10.1186/s12906-021-03456-2

PubMed:

34823510

Systematic exploration of the potential material basis and molecular mechanism of the Mongolian medicine Nutmeg-5 in improving cardiac remodeling after myocardial infarction.

Liu T et al (2022).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2021.114847

PubMed:

34800647

Neuroprotective Effects of Rhodiola Sacra on Transient Global Cerebral Ischemia Through Activating AMPK/Nrf2 Pathway in Rats.

Rhodiola sacra is a component with many medicinal uses, including anti-oxidation and anti-inflammation. Researchers investigated its neuroprotective effects against transient global cerebral ischemia (tGCI) in male rats. They found that pretreatment or/and post-treatment significantly reduced neuronal injury, inhibited glial activation, and improved cognitive function. Molecular docking showed that Rhodiola sacra targets adenosine monophosphate-activated protein kinase (AMPK) α2-subunit and upregulates phosphorylated AMPK and nuclear factor erythroid 2-related factor 2 (Nrf2). Additionally, Rhodiola sacra increased heme oxygenase-1 (HO-1) expression and activity and reduced malondialdehyde (MDA) content in the hippocampal CA1 region. These findings demonstrate that Rhodiola sacra prevents oxidant stress and protects neurons through activating the AMPK/Nrf2 pathway.

Li K et al (2022).

Antioxid Redox Signal.

DOI:

10.1089/ars.2020.8224

PubMed:

34714119

Pharmacological evaluation of Euphorbia hirta, Fagonia indica and Capparis decidua in hypertension through in-vivo and in vitro-assays.

Ali MZ et al (2021).

Heliyon.

DOI:

10.1016/j.heliyon.2021.e08094

PubMed:

34712851

Efficacy of Hibiscus sabdariffa on Reducing Blood Pressure in Patients With Mild-to-Moderate Hypertension: A Systematic Review and Meta-Analysis of Published Randomized Controlled Trials.

Hibiscus sabdariffa significantly reduces blood pressure in patients with mild-to-moderate hypertension, but not in patients with metabolic syndrome or when compared to antihypertensive drugs. More research is needed for long-term efficacy.

Abdelmonem M et al (2022).

J Cardiovasc Pharmacol.

DOI:

10.1097/FJC.0000000000001161

PubMed:

34694241