Cardiology Studies

Gypenosides exert cardioprotective effects by promoting mitophagy and activating PI3K/Akt/GSK-3β/Mcl-1 signaling.

Study on Gypenosides (GYPs) in Thunb. Makino plant shows potential for anti-aging and treating age-related conditions like diabetes. GYPs preserve mitochondrial function and prevent heart failure. Important for cardiovascular health research.

Zheng Y et al (2024).
PeerJ.
PubMed:
38912051

Gastrodin prevents myocardial injury in sleep-deprived mice by suppressing ferroptosis through SIRT6.

Gastrodin from orchid plant reduces cardiac injury caused by sleep deprivation by inhibiting ferroptosis through SIRT6 pathway. Important for understanding sleep deprivation effects on heart health.

Wu Y et al (2024).
Naunyn Schmiedebergs Arch Pharmacol.
PubMed:
38896272

Investigating the Pharmacological Mechanisms of Total Flavonoids from Eucommia ulmoides Oliver Leaves for Ischemic Stroke Protection.

Study shows total flavonoids from EUL leaves can protect against nerve damage from ischemia by reducing oxidative stress, increasing cell survival rates, and modulating related pathways, suggesting potential therapeutic effects for ischemic stroke treatment.

Qin J et al (2024).
Int J Mol Sci.
PubMed:
38892459

Benzoylaconine Protects Skeletal Muscle Against Ischemia-Reperfusion Injury Through Activation of IF1-Dependent AMPK/Nrf2 Axis.

Researchers identified Benzoylaconine (BAC) as a key compound in (Fuzi) used to treat pain and muscle ailments. BAC shows promise for pharmacological applications.

Cui Y et al (2024).
Drug Des Devel Ther.
PubMed:
38882050

Gypenoside A Protects Human Myocardial Cells from Ischemia/Reperfusion Injury via the circ_0010729/miR-370-3p/RUNX1 Axis.

Gypenoside A from Gynostemma pentaphyllum protects heart cells from ischemia/reperfusion injury by regulating circ_0010729/miR-370-3p/RUNX1 axis. Potential treatment for cardiovascular disease.

Ma H et al (2024).
Biochemistry (Mosc).
PubMed:
38880656

Gastrodin Ameliorates Post-Stroke Depressive-Like Behaviors Through Cannabinoid-1 Receptor-Dependent PKA/RhoA Signaling Pathway.

Research showed that the herbal extract gastrodin relieved depression in stroke patients by restoring synaptic proteins and spine density in the brain. This effect is mediated by CB1R, PKA, and RhoA signaling pathways, suggesting Gas could be a potential treatment for post-stroke depression.

Wang S et al (2024).
Mol Neurobiol.
PubMed:
38856794

Research of the dynamic regulatory mechanism of Compound Danshen Dripping Pills on myocardial infarction based on metabolic trajectory analysis.

Tossers studied CDDP for MI treatment, but focused on endpoints, neglecting dynamic changes in disease. Establishing dynamic research strategy for precise clinical medication guidance is crucial.

Zhang CJ et al (2024).
Phytomedicine.
PubMed:
38850631

Anti-oxidative and anti-inflammatory effects of Ginkgo biloba extract (EGb761) on hindlimb skeletal muscle ischemia-reperfusion injury in rats.

Researchers found that Ginkgo biloba extract can protect muscles from injury during spine surgery by reducing inflammation and oxidative stress. This could improve surgical outcomes and recovery.

Chen LY et al (2024).
Physiol Rep.
PubMed:
38839736