Covid-19 Studies

Computational Approaches to Designing Antiviral Drugs against COVID-19: A Comprehensive Review.

This review explores the use of computational techniques and AI in developing antiviral agents for COVID-19. It identifies potential compounds and stresses the need for experimental validation to expedite the search for effective treatments.

AntimicrobialCOVID-19 Tinospora cordifolia
Singh MP et al (2023).
Curr Pharm Des.
DOI:
10.2174/0113816128259795231023193419
PubMed:
37916490

In vitro anti-severe acute respiratory syndrome coronavirus 2 effect of Ephedra przewalskii Stapf extract.

The study explores the potential of Ephedra przewalskii extract as a treatment for infectious diseases. While E. sinica extract is used in traditional medicines, it has side effects. E. przewalskii extract is ephedrine-free but lacks sufficient evidence for its antiviral efficacy.

COVID-19 Ephedra sinica
Kakimoto M et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117341
PubMed:
37879507

Explore intersection genes of oxymatrine and COVID-19 with lung cancer as potential therapeutic targets based on network pharmacology.

Oxymatrine, a natural alkaloid, has antiviral, anti-inflammatory, and immune regulatory effects. Research suggests it may be beneficial for lung cancer patients with COVID-19. Targets include immune regulation, cytoprotection, and control of signaling pathways. Oxymatrine may enhance current treatments for COVID-19 and lung cancer.

COVID-19CancerGenetics Sophora flavescens
Wu W et al (2023).
J Med Microbiol.
DOI:
10.1099/jmm.0.001766
PubMed:
37855710

Efficacy and safety of licorice (Glycyrrhiza glabra) in moderately ill patients with COVID-19: a randomized controlled trial.

This study tested licorice extract as a treatment for COVID-19. The results showed that licorice did not significantly improve symptoms like body temperature and respiratory rate, but it did improve levels of CRP and ALT. Licorice was found to be safe, but larger trials are needed to confirm these results.

COVID-19 Glycyrrhiza glabra
Ameri A et al (2023).
Inflammopharmacology.
DOI:
10.1007/s10787-023-01352-4
PubMed:
37847472

Antiviral, virucidal and antioxidant properties of Artemisia annua against SARS-CoV-2.

The study found that extracts from Artemisia annua (sweet wormwood) have virucidal, antiviral, and antioxidant effects against COVID-19. Specific compounds from the plant show potential in inhibiting viral replication. Therefore, A. annua could be useful in fighting SARS-CoV-2 variants and future coronaviruses.

AntimicrobialCOVID-19Immunology Artemisia annua
Baggieri M et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.115682
PubMed:
37832410

Multifunctional natural derived carbon quantum dots from Withania somnifera (L.) - Antiviral activities against SARS-CoV-2 pseudoviron.

Researchers synthesized nitrogen-doped carbon dots from Withania somnifera, which showed improved fluorescence properties and potential for inhibiting SARS-CoV pseudoviron cells. Mechanism of action understanding is crucial for their potential use against Covid-19.

AntimicrobialCOVID-19 Withania somnifera
Nair A et al (2023).
Environ Res.
DOI:
10.1016/j.envres.2023.117366
PubMed:
37827368

Molecular networking unveils anti-SARS-CoV-2 constituents from traditionally used remedies.

Plants and fungi have historically been used for treating infections, including viruses. Some of these natural products have shown promise in fighting SARS-CoV-2 and related conditions, when approved therapeutics are limited.

COVID-19 Angelica sinensisAnnona squamosaAzadirachta indicaBuddleja officinalisBurkea africana
Wasilewicz A et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117206
PubMed:
37783406
1 9 10 11 20 38