Diabetes Studies

The Ethyl Acetate Extract of Phyllanthus emblica L. Alleviates Diabetic Nephropathy in a Murine Model of Diabetes.

Study examined the protective effects of Oil-Gan fruit extract on diabetic nephropathy in mice, improving kidney function and reducing inflammation and fibrosis. EPE may be a potential treatment for renal dysfunction.

Lin CH and Shih CC (2024).
Int J Mol Sci.
PubMed:
38928391

Network Pharmacology Analysis, Molecular Docking Integrated Experimental Verification Reveal the Mechanism of Gynostemma pentaphyllum in the Treatment of Type II Diabetes by Regulating the IRS1/PI3K/Akt Signaling Pathway.

Goldenroot (GP) has potential in treating type 2 diabetes mellitus (T2DM). GP contains 32 components and 326 potential targets related to T2DM, acting through insulin resistance signaling pathways. GP extracts increased glucose uptake and glycogen synthesis, suggesting a potential therapy for T2DM.

Yang S et al (2024).
Curr Issues Mol Biol.
PubMed:
38921004

Exploring the Potential of Ribes nigrum L., Aronia melanocarpa (Michx.) Elliott, and Sambucus nigra L. Fruit Polyphenol-Rich Composition and Metformin Synergy in Type 2 Diabetes Management.

Polyphenol-rich blend with metformin may improve management of type 2 diabetes by reducing insulin levels, glucose concentrations, and potential side effects. Further research needed for safety and efficacy.

Zima K et al (2024).
J Diabetes Res.
PubMed:
38919261

Corrections to "Phytochemical Screening and Antidiabetic Efficacy of Balanites aegyptiaca Seed Extract and Their Silver Nanoparticles on Muscle and Pancreatic Cell Lines".

Scientists synthesized new class of molecules with potential anti-cancer properties, enhancing drug delivery systems. Promising for future cancer treatments.

Bhardwaj M et al (2024).
ACS Omega.
PubMed:
38911749

Synthesis and characterization of Pyrus communis fruit extract synthesized ZnO NPs and assessed their anti-diabetic and anti-microbial potential.

Researchers synthesized zinc oxide nanoparticles from Pyrus communis fruit extract, which showed potential for anti-diabetic and anti-microbial properties. The nanoparticles were effective against certain bacteria and compared well with standard medications.

Elankathirselvan K et al (2024).
Environ Res.
PubMed:
38901812

Optimized extraction, enrichment, identification and hypoglycemic effects of triterpenoid acids from Hippophae rhamnoides L pomace.

Researchers optimized extraction and identified 13 triterpenoid acids in Hippophae rhamnoides L. pomace. TPF showed strong inhibition of α-glucosidase, reducing postprandial glucose levels and improving serum lipid profiles. Pomace may be valuable for functional foods.

Tie F et al (2024).
Food Chem.
PubMed:
38901339

Purpurin ameliorated neuropathic allodynia and hyperalgesia by modulating neuronal mitochondrial bioenergetics and redox status in type 1 diabetic mice.

Purpurin, a compound from Rubia tinctorum, relieves neuropathic pain in diabetic mice by enhancing bioenergetics and antioxidant effects. Could lead to improved therapy for diabetic patients with peripheral neuropathy.

Chen W et al (2024).
Eur J Pharmacol.
PubMed:
38897444

In Vitro and Molecular Docking Evaluation of the Anticholinesterase and Antidiabetic Effects of Compounds from Terminalia macroptera Guill. & Perr. (Combretaceae).

Compounds from a medicinal plant inhibit cholinesterases and are potential therapies for Alzheimer's disease and diabetes. Ellagic acid derivatives show promising enzyme inhibition. Good for your research!

Feunaing RT et al (2024).
Molecules.
PubMed:
38893333