Gastroenterology Studies

Cytotoxicity of Physalis minima Linn (Solanaceae) fruit against HCT116 and HT29 colorectal cancer cell lines.

Researchers studied the fruit of for potential cancer-fighting properties. Extracts showed cytotoxic effects on colorectal cancer cells, inducing programmed cell death. Identified 71 metabolites with anticancer properties. This study supports the medicinal potential of fruit extracts for cancer treatment.

Ng WL et al (2024).
Nat Prod Res.
PubMed:
38953123

Astragalus mongholicus Bunge and Curcuma aromatica Salisb. modulate gut microbiome and bile acid metabolism to inhibit colon cancer progression.

AC medicinal plants have promising effects on colon cancer therapy due to their impact on gut microbiome and bile acid metabolism. Understanding their mechanisms can lead to improved treatment strategies for digestive tract tumors.

Wang X et al (2024).
Front Microbiol.
PubMed:
38952445

Design of chitosan colon delivery micro/nano particles for an Achillea millefolium extract with antiproliferative activity against colorectal cancer cells.

Researchers designed micro/nanoparticles using chitosan to encapsulate a yarrow extract with anticancer properties. Spray-drying microparticles showed high encapsulation efficiency and effective release of phenolic compounds, making them a promising vehicle for delivering potential cancer-fighting agents to the colon.

Siles-Sánchez MLN et al (2024).
Drug Deliv.
PubMed:
38952133

Atractylenolide II combined with Interferon-γ synergistically ameliorates colorectal cancer progression in vivo and in vitro by blocking the NF-kB p65/PD-L1 pathway.

Koidz herbal medicine combined with IFN-γ inhibits CRC progression by regulating NF-kB p65/PD-L1 pathway. Effective against CRC cells and xenograft tumors in mice, shows potential for tumor immunotherapy.

Wu Y et al (2024).
J Cancer.
PubMed:
38947390