Gut enterotype-dependent modulation of gut microbiota and their metabolism in response to xanthohumol supplementation in healthy adults.

Xanthohumol (XN), a compound in hops, has health benefits. A study found that XN does not significantly change gut microbiota composition, but does affect individual taxa and bile acid metabolism in an enterotype-dependent way. Individual responses to XN vary, suggesting personalized effects on gut health.

Jamieson PE et al (2024).

Gut Microbes.

DOI:

10.1080/19490976.2024.2315633

PubMed:

38358253

Cannabidiol activates MAPK pathway to induce apoptosis, paraptosis, and autophagy in colorectal cancer cells.

CBD, found in Cannabis sativa, induces cell death in colorectal cancer cells. It activates the MAPK pathway, leading to apoptosis, paraptosis, and autophagy. This suggests that CBD could be a potential treatment for colorectal cancer.

Kim NY et al (2024).

J Cell Biochem.

DOI:

10.1002/jcb.30537

PubMed:

38358093

Apium extract alleviates indomethacin-induced gastric ulcers in rats via modulating the VEGF and IK-κB/NF-κB p65 signaling pathway: insights from in silico and in vivo investigations.

Researchers studied the potential of celery seed extract to prevent indomethacin-induced stomach ulcers in rats. This may lead to a new treatment or prevention approach for gastric ulcers.

Abu-Baih DH et al (2024).

BMC Complement Med Ther.

DOI:

10.1186/s12906-023-04333-w

PubMed:

38355510

Effect of Polygonatum sibiricum saponins on gut microbiota of mice with ulcerative colitis.

Polygonatum sibiricum saponins (PSS) improved symptoms and pathology in colitis mice induced with dextran sulfate sodium (DSS). PSS restored intestinal microbial balance, reduced pathogenic bacteria, and increased beneficial bacteria, suggesting its potential therapeutic role in ulcerative colitis.

Cao R et al (2024).

Fitoterapia.

DOI:

10.1016/j.fitote.2024.105855

PubMed:

38354822

Assessing the Gut Microbiota's Ability to Metabolize Oligomeric and Polymeric Flavan-3-ols from Aronia and Cranberry.

Lessard-Lord J et al (2024).

Mol Nutr Food Res.

DOI:

10.1002/mnfr.202300641

PubMed:

38350729

Intestinal Microbiome Metabolism of Cranberry (Vaccinium macrocarpon) Proanthocyanidin Dimers, but Not Trimers, Is Altered by Dysbiosis in Ulcerative Colitis Ex Vivo.

Cranberries have chemical variations that affect how they are metabolized by gut bacteria. Healthy microbiomes produce more beneficial compounds from cranberries than ulcerative colitis microbiomes. The metabolism of a specific cranberry compound called procyanidin B2 is key for this difference.

Diaz MS, Mertens-Talcott SU and Talcott ST (2024).

J Agric Food Chem.

DOI:

10.1021/acs.jafc.4c00042

PubMed:

38350030

Effects of the protective and therapeutic effect of yogurt enriched with Citrus sinensis essential oil against ibuprofen-induced gastric ulcer in elderly rats.

This study found that adding Citrus sinensis essential oil to yogurt increased acidity, total solids, and ash values. Rats fed with this functional yogurt had fewer gastric ulcer lesions compared to the control group. This suggests that yogurt with C. sinensis EO may help reduce the severity of ulcers and improve health.

Polat Z et al (2024).

J Food Sci.

DOI:

10.1111/1750-3841.16937

PubMed:

38349052

Complex insoluble dietary fiber alleviates obesity and liver steatosis, and modulates the gut microbiota in C57BL/6J mice fed a high-fat diet.

Researchers studied the effects of insoluble dietary fiber (IDF) on obesity, inflammation, and diabetes. IDF has positive effects on these conditions, making it important for overall health.

Liu Z et al (2024).

J Sci Food Agric.

DOI:

10.1002/jsfa.13380

PubMed:

38348948