Gastroenterology Studies

Baicalin Induces Gastric Cancer Cell Pyroptosis through the NF-κB-NLRP3 Signaling Axis.

Baicalein, a component in traditional Chinese medicine, induces pyroptosis in gastric cancer cells through the NF-κB-NLRP3 signaling axis. This could be an effective and novel therapeutic approach for treating gastric cancer, providing hope for improved outcomes.

Liu J et al (2024).
J Cancer.
PubMed:
38169542

Rattan Pepper Polysaccharide Regulates DSS-Induced Intestinal Inflammation and Depressive Behavior through Microbiota-Gut-Brain Axis.

This study found that rattan pepper polysaccharide (RPP) can reduce intestinal inflammation and depression-like behavior in mice with inflammatory bowel disease (IBD). RPP improves gut microbiota balance, reduces brain inflammation, and enhances synaptic function. This suggests that RPP may have potential therapeutic effects for IBD and associated depression.

Chang L et al (2024).
J Agric Food Chem.
PubMed:
38164789

Mulberry (Morus alba L.) leaf water extract attenuates type 2 diabetes mellitus by regulating gut microbiota dysbiosis, lipopolysaccharide elevation and endocannabinoid system disorder.

Researchers found that mulberry leaf water extract (MLWE) can improve type 2 diabetes by regulating gut microbiota and reducing intestinal permeability. This is important for understanding the potential benefits of MLWE in treating metabolic dysfunction.

Du Y et al (2023).
J Ethnopharmacol.
PubMed:
38163557

Piperine promotes PI3K/AKT/mTOR-mediated gut-brain autophagy to degrade α-Synuclein in Parkinson's disease rats.

Scientists studied the herb Piper longum and its main compound, piperine, to understand how it protects against Parkinson's disease. They found that piperine promotes a process called autophagy, which helps degrade harmful proteins in the gut and brain. This research may lead to new treatments for Parkinson's disease.

Yu L et al (2023).
J Ethnopharmacol.
PubMed:
38158101