Gastroenterology Studies

Brucine D restrains colorectal cancer tumorigenesis and autophagy by downregulating circ_0068464.

Bruceine D (BD) from Brucea javanica inhibits colorectal cancer (CRC) cell proliferation, invasion, and autophagy, while promoting apoptosis. This is mediated by BD's regulation of the circ_0068464/miR-520h/ATG5 axis, suggesting potential as a CRC treatment.

Yang Y et al (2023).
Chem Biol Drug Des.
PubMed:
38040413

Pulsatillae radix extract alleviates DSS-induced colitis via modulating gut microbiota and inflammatory signaling pathway in mice.

Researchers studied the effectiveness and mechanisms of Baitouweng decoction (BD), a Traditional Chinese Medicine, in treating ulcerative colitis (UC). Understanding this could help improve UC treatment, reducing its global impact on public health.

Li X et al (2023).
Heliyon.
PubMed:
38034600

Identification of Potential Phytochemical Inhibitors From Conium maculatum Targeting the Epidermal Growth Factor Receptor in Metastatic Colorectal Cancer via Molecular Docking Analysis.

Scientists screened phytochemicals from a plant as potential inhibitors of EGFR in metastatic colorectal cancer (mCRC). 25 compounds had favorable drug-like properties, with 12 showing high affinity for EGFR. Seven compounds were predicted to be safe and effective, warranting further investigation and optimization.

Venkateswaran S et al (2023).
Cureus.
PubMed:
38034159