Network pharmacology-based anti-colorectal cancer activity of piperlonguminine in the ethanolic root extract of Piper longum L.

Researchers studied the ethanolic root extract of Piper longum and identified piperlonguminine as a potential medicine for colorectal cancer. Hub genes SRC, MTOR, EZH2, and MAPK3 were found to be involved in cancer-related pathways that could be targeted for treatment. Piperlonguminine shows promise as a future CRC medicine.

Singh I, Das R and Kumar A (2023).

Med Oncol.

DOI:

10.1007/s12032-023-02185-5

PubMed:

37796360

Mangiferin alleviates trimethylamine-N-oxide (TMAO)-induced atherogenesis and modulates gut microbiota in mice.

He Z et al (2023).

Food Funct.

DOI:

10.1039/d3fo02791k

PubMed:

37781894

Effect of free and bound polyphenols from Rosa roxburghii Tratt distiller's grains on moderating fecal microbiota.

Zhou D et al (2023).

Food Chem X.

DOI:

10.1016/j.fochx.2023.100747

PubMed:

37780293

Thermal treatment enhances the resisting exercise fatigue effect of Phyllanthus emblica L.: novel evidence from tannin conversion in vitro, metabolomics, and gut microbiota community analysis.

Zhang D et al (2023).

Chin Med.

DOI:

10.1186/s13020-023-00835-4

PubMed:

37779204

Moringa oleifera leaf polysaccharide regulates fecal microbiota and colonic transcriptome in calves.

Zhao C et al (2023).

Int J Biol Macromol.

DOI:

10.1016/j.ijbiomac.2023.127108

PubMed:

37776927

Curculigoside mitigates dextran sulfate sodium‑induced colitis by activation of KEAP1‑NRF2 interaction to inhibit oxidative damage and autophagy of intestinal epithelium barrier.

Curculigoside (CUR) has anti-inflammatory effects and helps maintain intestinal barrier function. It activates Nrf2 via Keap1/Nrf2 interaction, reducing oxidative stress and promoting autophagy. CUR can effectively treat colitis and may be used in UC therapy.

Li F et al (2023).

Int J Mol Med.

DOI:

10.3892/ijmm.2023.5310

PubMed:

37772380

Prunella vulgaris L. attenuates gut dysbiosis and endotoxin leakage against alcoholic liver disease.

Scientists studied the herb Prunella vulgaris L. (PVL) and its potential benefits for the liver. PVL has been traditionally used to protect liver function and has shown potential in treating liver diseases. However, the specific mechanisms by which it benefits mice with alcoholic liver disease (ALD) are still unknown.

Rao PL et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117237

PubMed:

37769885

Modulation of chicken gut contractility by Melissa officinalis-ex vivo study.

Lemon balm extract, commonly used in traditional medicine for gastrointestinal disorders, was found to increase gut contractility in broiler chickens. This contradicts its use as a treatment for gut motility disturbances and diarrhea in animals.

Posłuszny MA et al (2023).

Poult Sci.

DOI:

10.1016/j.psj.2023.103045

PubMed:

37769497