Gastroenterology Studies

Thymoquinone-loaded lipid nanocapsules with promising anticancer activity for colorectal cancer.

Thymoquinone (TQ), found in black seeds, was tested as a treatment for colorectal cancer in mice. When encapsulated in lipid nanocapsules, TQ effectively reduced tumor size and induced tumor cell death, making it a potential anticancer agent for colorectal cancer treatment.

Selmi M et al (2023).
Nanoscale Adv.
PubMed:
37767034

Piper nigrum Extract Inhibits the Growth of Human Colorectal Cancer HT-29 Cells by Inducing p53-Mediated Apoptosis.

Researchers investigated the effect of a plant extract (PNE) on colorectal cancer (CRC) cells. PNE was found to inhibit cell proliferation, induce apoptosis, and inhibit tumor growth by regulating p53 and activating the caspase-3 pathway. PNE could be a potential natural anti-CRC drug candidate.

Wu R et al (2023).
Pharmaceuticals (Basel).
PubMed:
37765133

Hibiscus Anthocyanins Extracts Induce Apoptosis by Activating AMP-Activated Protein Kinase in Human Colorectal Cancer Cells.

Hibiscus anthocyanin-rich extracts induce apoptosis in colorectal cancer cells by activating AMPK and Fas-mediated pathways, leading to caspase-3 cleavage and cell death. This highlights the potential of these extracts for cancer treatment.

Tsai MC et al (2023).
Nutrients.
PubMed:
37764756

Anti-Colorectal Cancer Activity of Solasonin from Solanum nigrum L. via Histone Deacetylases-Mediated p53 Acetylation Pathway.

Scientists studied Solanum nigrum L., a plant used to treat tumors, and found that its steroidal alkaloid Solasonin (SS) has anti-colorectal cancer (CRC) activity. SS induced apoptosis and cell cycle arrest in CRC cells by downregulating HDAC and increasing P53 acetylation. SS could effectively inhibit CRC growth, making it a potential treatment option.

Lan X et al (2023).
Molecules.
PubMed:
37764423

Effects of Anticoccidial Vaccination and Taraxacum officinale Extract on the Growth Performance, Biochemical Parameters, Immunity, and Intestinal Morphology of Eimeria-Challenged Chickens.

Arczewska-Włosek A et al (2023).
Life (Basel).
PubMed:
37763330

Effects of White Fish Meal Replaced by Low-Quality Brown Fish Meal with Compound Additives on Growth Performance and Intestinal Health of Juvenile American Eel (Anguilla rostrata).

Lu W et al (2023).
Animals (Basel).
PubMed:
37760273