Gastroenterology Studies

In Vitro Antiproliferative Apoptosis Induction and Cell Cycle Arrest Potential of Saudi Sidr Honey against Colorectal Cancer.

Sidr honey from Saudi Arabia was tested on colorectal, breast, and lung cancer cells. It showed potential as an antitumor agent by inducing apoptosis and cell cycle arrest. Further research is needed to identify and understand the active compounds.

Qanash H et al (2023).
Nutrients.
PubMed:
37571386

Terminalia bellirica Fruit Extract Alleviates DSS-Induced Ulcerative Colitis by Regulating Gut Microbiota, Inflammatory Mediators, and Cytokines.

This study found that ethyl acetate extract from fruits has anti-inflammatory effects and can alleviate symptoms of ulcerative colitis. It also suggests TBEA could be developed into a new drug for treating UC.

Li YY et al (2023).
Molecules.
PubMed:
37570753

Effects of Traditional Chinese Herbal Feed Additive on Production Performance, Egg Quality, Antioxidant Capacity, Immunity and Intestinal Health of Laying Hens.

A Chinese herbal feed additive (TCM) improved egg production, quality, antioxidant capacity, immunity, and intestinal health in Roman laying hens compared to control and antibiotic groups.

Liu B et al (2023).
Animals (Basel).
PubMed:
37570319

Exploring the Impact of Ampelopsis Grossedentata Flavonoids on Growth Performance, Ruminal Microbiota, and Plasma Physiology and Biochemistry of Kids.

This study found that supplementing Ampelopsis grossedentata flavonoids (AGF) in goat's diets improved rumen bacterial microbiome, plasma physiology, and growth performance. This has potential benefits for livestock growth and economic outcomes.

Zhu J et al (2023).
Animals (Basel).
PubMed:
37570263

Anti-Inflammatory and Gut Microbiota Modulation Potentials of Flavonoids Extracted from Passiflora foetida Fruits.

This study found that fruit extract reduced inflammation and altered gut microbiota, promoting beneficial bacteria and short-chain fatty acid production. It has potential as a natural anti-inflammatory agent.

Han X et al (2023).
Foods.
PubMed:
37569158

Targeting HSP90 with picropodophyllin suppresses gastric cancer tumorigenesis by disrupting the association of HSP90 and AKT.

Picropodophyllin (PPP), extracted from Dysosma versipellis, inhibits gastric cancer (GC) cell proliferation by inducing apoptosis. PPP blocks the AKT/mTOR signaling pathway by targeting heat shock protein 90 (HSP90), making it a potential therapeutic compound for GC treatment.

Li X et al (2023).
Phytother Res.
PubMed:
37559472

Plumbagin induces apoptosis, cell cycle arrest, and inhibits protein synthesis in LoVo colon cancer cells: A proteomic analysis.

Plumbagin, extracted from Plumbago zeylanica L., inhibits growth and induces apoptosis in LoVo colon cancer cells. Mechanisms include cell cycle arrest and disruption of protein synthesis. Potential therapeutic for colon cancer.

Shu J et al (2023).
Chem Biol Drug Des.
PubMed:
37558615

Polysaccharides from Tetrastigma Hemsleyanum Diels et Gilg ameliorated inflammatory bowel disease by rebuilding the intestinal mucosal barrier and inhibiting inflammation through the SCFA-GPR41/43 signaling pathway.

Tetrastigma hemsleyanum polysaccharide (THP) reduces inflammation, promotes intestinal barrier integrity, regulates gut microbiota, and activates SCFAs-GPR41/43 signaling pathway in inflammatory bowel disease.

Lin Y et al (2023).
Int J Biol Macromol.
PubMed:
37558022