Solamargine induces apoptosis of human renal carcinoma cells via downregulating phosphorylated STAT3 expression.
Solamargine (SM) inhibits tumor cell proliferation and induces apoptosis in human renal carcinoma cells. It downregulates p-STAT3 expression and activates caspase proteins, promoting cell death. SM also inhibits tumor growth in mice without causing organ toxicity.
- Huang S et al (2023).
- Oncol Lett.
- PubMed:
- 37854861