Immunology Studies

Memophenol(TM) Prevents Amyloid-β Deposition and Attenuates Inflammation and Oxidative Stress in the Brain of an Alzheimer's Disease Rat.

Researchers administered Memophenol, a polyphenol compound made from French grape and North American blueberry extracts, to rats with Alzheimer's disease (AD) for 30 days. The rats had been administered AlCl and D-galactose for 60 days and showed behavioral alterations and hippocampus neuronal degeneration. Memophenol reduced behavioral alterations and hippocampus neuronal degeneration, lowered phosphorylated Tau levels and APP overexpression, and reduced beta-amyloid buildup. The compound also reduced the pro-oxidative and pro-inflammatory hippocampus changes caused by AD. These findings suggest Memophenol could be a therapeutic option for AD.

Impellizzeri D et al (2023).
Int J Mol Sci.
PubMed:
37108102