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- PubMed:
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Researchers administered Memophenol, a polyphenol compound made from French grape and North American blueberry extracts, to rats with Alzheimer's disease (AD) for 30 days. The rats had been administered AlCl and D-galactose for 60 days and showed behavioral alterations and hippocampus neuronal degeneration. Memophenol reduced behavioral alterations and hippocampus neuronal degeneration, lowered phosphorylated Tau levels and APP overexpression, and reduced beta-amyloid buildup. The compound also reduced the pro-oxidative and pro-inflammatory hippocampus changes caused by AD. These findings suggest Memophenol could be a therapeutic option for AD.