Immunology Studies

Elucidating the promising role of traditional Chinese medicine in neuroprotection against oxidative stress encompassing Alzheimer's disease.

Traditional Chinese Medicine (TCM) has shown potential in managing Alzheimer's disease (AD) by breaking the vicious cycle of oxidative stress and neurodegeneration. The active constituents of various herbs in TCM have a long history in managing oxidative stress and have highlighted therapeutic potential. Chinese herbs provide a multiple-target approach, which can target multiple pathways involved in AD, and untangle the issues in the current therapy regimen of AD. This review suggests that TCM is a promising candidate for breaking the vicious cycle of oxidative stress in AD therapy.

Arora A et al (2023).
Environ Sci Pollut Res Int.
PubMed:
36790717

Essential oil of Acorus tatarinowii Schott inhibits neuroinflammation by suppressing NLRP3 inflammasome activation in 3 × Tg-AD transgenic mice.

Researchers studied the effects of Shi chang pu (SCP-oil) on the neuroinflammation of Alzheimer's disease. SCP-oil is the main active component of Acorus tatarinowii Schott, a herbal used for AD treatment in China. Results showed that SCP-oil reduced neuroinflammation in the brains of AD model rats by inhibiting the activation of microglia. This study suggests that SCP-oil may have potential as a therapeutic agent for AD.

Xu Z et al (2023).
Phytomedicine.
PubMed:
36774844