Immunology Studies

Carica Papaya Reduces High Fat Diet and Streptozotocin-Induced Development of Inflammation in Adipocyte via IL-1β/IL-6/TNF-α Mediated Signaling Mechanisms in Type-2 Diabetic Rats.

Rebecca Roy J et al (2023).
Curr Issues Mol Biol.
PubMed:
36826001

Sarglamides A-E, Indolidinoid-Monoterpenoid Hybrids with Anti-neuroinflammatory Activity from a Sarcandra Species.

Researchers isolated Sarglamides A-E from a plant and found that compounds - and - have unique structures. They proposed possible pathways for their creation and found that compounds - can reduce inflammation.

Zhou B et al (2023).
Org Lett.
PubMed:
36825855

Aerial part of Houttuynia cordata reverses memory impairment by regulating amyloid beta accumulation and neuroinflammation in Alzheimer's disease model.

An herbal medicine, Houttuyniae Herba (HH), traditionally used to treat various ailments, has been found to protect neurons and regulate dysfunction in Alzheimer's disease (AD) models. Administered to transgenic mice, HH reduced amyloid-β accumulation and improved memory impairment. In vitro, HH inhibited amyloid-β aggregation and increased alpha-secretase expression. With anti-neuroinflammatory effects, HH reduced glial activation and increased synaptophysin expression. HH may be a promising herbal drug for AD patients in need of multiple improvements.

Ju IG et al (2023).
Phytother Res.
PubMed:
36814130