Garlic (Allium sativum L.) as an Ally in the Treatment of Inflammatory Bowel Diseases.
- Zugaro S, Benedetti E and Caioni G (2023).
- Curr Issues Mol Biol.
- DOI:
- 10.3390/cimb45010046
- PubMed:
- 36661532
Curcumin, a natural compound found in turmeric, was investigated for its potential to reduce opioid dependence in rats. The study used immunofluorescence staining and ELISA methods to evaluate cytokine levels, and western blotting to evaluate the expression of μ-opioid receptors. Results showed that curcumin administration significantly attenuated the symptoms of morphine withdrawal syndrome and reduced cytokine levels and inflammation in the prefrontal cortex. Additionally, the expression of μ-opioid receptors was reduced by curcumin. This study highlights the potential of curcumin as a treatment for opioid dependence by targeting neuroinflammation.