Aqueous extract of Ceratonia siliqua L. leaves elicits antioxidant, anti-inflammatory, and AChE inhibiting effects in amyloid-β42-induced cognitive deficit mice: Role of α7-nAChR in modulating Jak2/PI3K/Akt/GSK-3β/β-catenin cascade.

Researchers investigated the effects of Ceratonia siliqua extract on Alzheimer's disease (AD) in mice. AD is caused by several factors including neuroinflammation, oxidative stress, and amyloid buildup. Mice injected with amyloid-β42, a protein involved in AD, were treated with the extract. The extract improved brain function and reduced AD symptoms, including inflammation and oxidative stress. Researchers found that the extract works by modulating specific pathways, which are involved in AD, in an α7-nAChR-dependent manner. The study suggests that Ceratonia siliqua could be a promising treatment for AD.

El Sayed NS et al (2023).

Phytother Res.

DOI:

10.1002/ptr.7766

PubMed:

36760217

Salvianolic acid A attenuates inflammation-mediated atherosclerosis by suppressing GRP78 secretion of endothelial cells.

Fan X et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.116219

PubMed:

36758912

A review on curcumin colon-targeted oral drug delivery systems for the treatment of inflammatory bowel disease.

Sardou HS et al (2023).

Inflammopharmacology.

DOI:

10.1007/s10787-023-01140-0

PubMed:

36757584

Matrine regulates Th1/Th2 inflammatory responses by inhibiting the Hsp90/NF-κB signaling axis to alleviate atopic dermatitis.

Huang P et al (2023).

Kaohsiung J Med Sci.

DOI:

10.1002/kjm2.12655

PubMed:

36757049

Bioactive substances inhibiting COX-2 and cancer cells isolated from the fibrous roots of Alangium chinense (Lour.) Harms.

Xiao T et al (2023).

RSC Adv.

DOI:

10.1039/d2ra06931h

PubMed:

36756416

Effects of polysaccharides from Gastrodia elata on the immunomodulatory activity and gut microbiota regulation in cyclophosphamide-treated mice.

Li N et al (2023).

J Sci Food Agric.

DOI:

10.1002/jsfa.12491

PubMed:

36754603

Structural characterization and anti-inflammatory activity of a novel neutral polysaccharide isolated from Smilax glabra Roxb.

Huang Y et al (2023).

Int J Biol Macromol.

DOI:

10.1016/j.ijbiomac.2023.123559

PubMed:

36754268

Anti-inflammatory role of Artemisia argyi methanol extract by targeting the caspase-11 non-canonical inflammasome in macrophages.

Kim YB, Cho HJ and Yi YS (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.116231

PubMed:

36754190