Treadmill running and Levisticum Officinale extract protect against LPS-induced memory deficits by modulating neurogenesis, neuroinflammation and oxidative stress.
Exercise and Levisticum officinale extract can protect against Alzheimer's disease by reducing neuroinflammation. In a study with male Wister rats, a week of treadmill running and/or treatment with Levisticum officinale extract for a week, followed by three weeks of treadmill running and/or treatment, improved spatial learning and memory, reduced levels of interleukin-6 and malondialdehyde, and increased superoxide dismutase activity and neurogenesis in the hippocampus. These results suggest that the antioxidant and anti-inflammatory properties of Levisticum officinale extract may help prevent or mitigate Alzheimer's disease.
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- Metab Brain Dis.
- PubMed:
- 36478529