Immunology Studies

The Structural, Biological, and In-Silico Profiling of Novel Capryloyl Tetra-Glucoside and Aliphatic Ester Constituents from the Abutilon indicum Offers New Perspectives on the Treatment of Pain and Inflammation.

Peeli booti plant from India was studied to identify and evaluate its ability as an anti-inflammatory and analgesic. Two novel compounds were found with potential therapeutic targets for development of such drugs.

Wahab S et al (2022).
Plants (Basel).
PubMed:
36235451

Anti-Apoptotic and Anti-Inflammatory Effects of an Ethanolic Extract of Lycium chinense Root against Particulate Matter 10-Induced Cell Death and Inflammation in RBL-2H3 Basophil Cells and BALB/c Mice.

Lee J et al (2022).
Plants (Basel).
PubMed:
36235350

The Isolation and Preparation of Samwinol from Dracocephalum heterophyllum and Prevention on Aβ(25-35)-Induced Neuroinflammation in PC-12 Cells.

Scientists obtained samwinol from traditional Chinese Tibetan medicine by chromatography separation and investigated its effects on protecting cells against neurotoxicity caused by amyloid beta protein fragment. The results showed that samwinol increased cell viability, inhibited the production of reactive oxygen species, and suppressed ERK/AKT phosphorylation while promoting Nrf2/HO-1 signaling. Samwinol has significant anti-neuroinflammatory and antioxidant activities, suggesting its potential use for treating Alzheimer's disease. Further studies are needed to confirm its efficacy.

Li C et al (2022).
Int J Mol Sci.
PubMed:
36232874