Pergularia daemia hydro-ethanolic extract protects against pentylenetetrazole kindling-induced seizures, oxidative stress, and neuroinflammation in mice.

Researchers investigated the antiepileptic potential of Pergularia daemia, a medicinal plant used in Cameroon to treat epilepsy. Traditional healers claim the hydro-ethanolic extract of its roots is more effective than an aqueous extract on refractory seizures. This study aimed to test that claim using mice models of epilepsy. The findings suggest that the hydro-ethanolic extract may have better anticonvulsant activity than the aqueous extract, indicating P. daemia's potential as a source for new antiepileptic drugs. However, further studies are needed to validate these findings.

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PubMed:

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34134180

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