Immunology Studies

Effect of Argemone mexicana on Local Edema and LPS-Induced Neuroinflammation.

Scientists investigated the anti-inflammatory properties of Argemone mexican L., a plant commonly used in Mexican traditional medicine. They tested an extract (AmMeOH), a fraction extracted with ethyl acetate (AmAcOEt), and four sub-fractions (AmF-1 to AmF-4) for their effectiveness against inflammation caused by 2-O-tetradecanoylphorbol-13-acetate (TPA) and neuroinflammation caused by lipopolysaccharides (LPS). Treatment with AmAcOEt and AmF-3 showed the greatest reduction in inflammation and pro-inflammatory cytokines in the spleen and brain of mice with neuroinflammation. AmF-3 contains three flavonoids, including isoquercetin, which had the highest concentration. These findings suggest that A. mexican L. may have beneficial effects on inflammatory and nervous medical conditions.

Monterrosas-Brisson N et al (2021).
Chem Biodivers.
PubMed:
33527713

Vitex negundo Linn. extract alleviates inflammatory aggravation and lung injury by modulating AMPK/PI3K/Akt/p38-NF-κB and TGF-β/Smad/Bcl2/caspase/LC3 cascade and macrophages activation in murine model of OVA-LPS induced allergic asthma.

Researchers studied the potential of Vitex negundo Linn., a medicinal plant, in managing allergic respiratory diseases. Its anti-tussive and bronchodilator properties suggest it could be beneficial for asthma. However, more scientific research is needed to understand its exact attributes and mechanism of action.

Tirpude NV et al (2021).
J Ethnopharmacol.
PubMed:
33516930