Grindelia squarrosa Extract and Grindelic Acid Modulate Pro-inflammatory Functions of Respiratory Epithelium and Human Macrophages.
- Gierlikowska B et al (2021).
- Front Pharmacol.
- PubMed:
- 33536899
Scientists investigated the anti-inflammatory properties of Argemone mexican L., a plant commonly used in Mexican traditional medicine. They tested an extract (AmMeOH), a fraction extracted with ethyl acetate (AmAcOEt), and four sub-fractions (AmF-1 to AmF-4) for their effectiveness against inflammation caused by 2-O-tetradecanoylphorbol-13-acetate (TPA) and neuroinflammation caused by lipopolysaccharides (LPS). Treatment with AmAcOEt and AmF-3 showed the greatest reduction in inflammation and pro-inflammatory cytokines in the spleen and brain of mice with neuroinflammation. AmF-3 contains three flavonoids, including isoquercetin, which had the highest concentration. These findings suggest that A. mexican L. may have beneficial effects on inflammatory and nervous medical conditions.
Researchers studied the potential of Vitex negundo Linn., a medicinal plant, in managing allergic respiratory diseases. Its anti-tussive and bronchodilator properties suggest it could be beneficial for asthma. However, more scientific research is needed to understand its exact attributes and mechanism of action.