Immunology Studies

Anti-Neuroinflammatory ent-Kaurane Diterpenoids from Pteris multifida Roots.

Researchers have discovered potential new compounds that could serve as anti-neuroinflammatory agents by inhibiting the production of nitric oxide in activated microglia cells. The compounds were isolated from the roots of the Pteridaceae plant and include three new -kaurane diterpenoids, along with nine other known compounds. The new compounds were shown to reduce levels of pro-inflammatory mediators, such as PGE₂, TNF-α, IL-1β, and IL-6. These findings highlight the potential of -kaurane diterpenes from Pteridaceae as new agents in the fight against neurodegenerative diseases, including Alzheimer's disease.

Kim JW et al (2016).
Molecules.
PubMed:
28035965