Neuroscience Studies

Chitosan nanoparticles encapsulated Piper betle essential oil alleviates Alzheimer's disease associated pathology in Caenorhabditis elegans.

Encapsulating Piper betle oil in nanoparticles improved Alzheimer's symptoms in Caenorhabditis elegans, increasing lifespan and cognitive function while reducing Aβ deposits and neurotoxicity. The DAF-16 pathway was implicated in reducing Aβ toxicity.

NeurosciencePhytochemistry Piper betle
Velumani M et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.135323
PubMed:
39241994

The neuroprotective role of celastrol on hippocampus in diabetic rats by inflammation restraint, insulin signaling adjustment, Aβ reduction and synaptic plasticity alternation.

Celastrol from Tripterygium wilfordii protects diabetic rats against cognitive decline by improving insulin sensitivity, glucose tolerance, and reducing inflammation in the brain. Celastrol also promotes the synthesis of synaptic proteins, enhancing cognitive function.

DiabetesImmunologyNeuroscience Tripterygium wilfordii
Zhou Q et al (2024).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2024.117397
PubMed:
39232386

Lemongrass essential oil and its major component citronellol: evaluation of larvicidal activity and acetylcholinesterase inhibition against Anopheles sinensis.

Lemongrass essential oil and its major compound, citronellol, show promise as natural larvicides against malaria-carrying mosquitoes. Citronellol inhibits acetylcholinesterase activity, offering a potential alternative to chemical insecticides.

NeurosciencePhytochemistry Cymbopogon citratus
Tang Y, Li H and Song Q (2024).
Parasitol Res.
DOI:
10.1007/s00436-024-08338-3
PubMed:
39227462

Progress of Exosomal MicroRNAs and Traditional Chinese Medicine Monomers in Neurodegenerative Diseases.

Exosomes contain microRNAs crucial for intercellular communication in neurodegenerative diseases. Traditional Chinese medicine monomers show promise in treating these diseases by reducing oxidative stress, apoptosis, and inflammation. Study explores their potential synergy with modern therapies.

Neuroscience Ampelopsis grossedentata
Liang J et al (2024).
Phytother Res.
DOI:
10.1002/ptr.8322
PubMed:
39225243

Butylphthalide Mitigates Traumatic Brain Injury by Activating anti-Ferroptotic AHR-CYP1B1 Pathway.

Researchers explored the potential of 3-n-butylphthalide (NBP) in inhibiting ferroptosis, a cell death process linked to traumatic brain injury and neurodegenerative diseases. NBP, derived from Chinese celery, showed promising anti-ROS effects, suggesting potential for therapeutic development.

Neuroscience Apium graveolens
Yan L et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118758
PubMed:
39222762

Fungal Coculture of Herpotrichia sp. and Trametes versicolor Induces Production of Diverse Metabolites with Anti-Parkinson's Neuroprotective Activity.

Isopod-associated fungi produced 13 new compounds, including rare sesquiterpene-saccharide hybrids and a natural sesquiterpene racemate. These compounds protected neurons from oxidative damage, with compound potentially being a promising treatment for Parkinson's disease.

Neuroscience Trametes versicolor
Wang ZJ et al (2024).
J Nat Prod.
DOI:
10.1021/acs.jnatprod.4c00421
PubMed:
39214601

Therapeutic Evaluation of Unani Medicine, Including Single Drugs and Polyherbal Formulations with Special Reference to Neurodegenerative Disorders.

Unani remedies offer safer alternatives to conventional drugs for treating neurodegenerative disorders, with evidence supporting their efficacy in alleviating symptoms and providing neuroprotective benefits from natural phytoconstituents.

Neuroscience Acorus calamusPinus gerardianaWithania somnifera
Imran S, Ahmad W and Saltanat S (2024).
Altern Ther Health Med.
PubMed:
39212516

Alantolactone improves cognitive impairment in rats with Porphyromonas gingivalis infection by inhibiting neuroinflammation, oxidative stress, and reducing Aβ levels.

Alantolactone from Inula racemosa improved cognitive impairment in P. gingivalis-infected rats by reducing neuroinflammation, Aβ levels, and oxidative stress via Nrf2/HO-1 pathway activation.

ImmunologyNeuroscience Inula racemosa
Chen S et al (2024).
Brain Res.
DOI:
10.1016/j.brainres.2024.149203
PubMed:
39208968
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