Mesaconitine induces neurotoxicity by causing oxidative stress and mitochondrial damage, activating autophagy, and altering RNA methylation. Understanding these mechanisms enhances the safe use of aconitum in medicine.
MPR, a traditional Persian herbal formula, improves anxiety and depression in IBS-C patients. Supports potential natural treatment for mental health symptoms in IBS sufferers.
Study showed Ocimum basilicum essential oil and estragole have anxiolytic and anticonvulsant effects on zebrafish through modulation of GABA and 5-HT receptors, suggesting potential for new drug development.
Solid-state fermentation of soybeans increases polyphenol content, which can combat Alzheimer's disease. Conditions: 12 days fermentation, 15% inoculation, initial pH 2. Results: 4.98x free polyphenols, 2.38x bound polyphenols, 4.16x total phenols compared to unfermented soybeans. Free polyphenols inhibit acetylcholinesterase by 91.51%.
Researchers found an herbal extract called Sabroxy can significantly increase BDNF expression, supporting neuronal health and protecting against inflammation. Sabroxy's antioxidant properties could mitigate neurodegeneration damage. This suggests a potential therapeutic application for neurological disorders.
Study demonstrates potential benefits of liposomal ashwagandha supplementation on cognitive function and mood in young adults. May be useful for reducing stress and cognitive decline in younger populations.
AR has potential pharmacological effects for hypertension and cerebral ischemia. Further research needed for validation and possible use in medical treatment.
Scientists used in vivo and in silico approaches to identify potential Nav1.2 blockers for epilepsy management. Plant extracts showed promise in mice, with two compounds showing stable binding to Nav1.2. This research could lead to new, effective, and natural antiepileptic drugs with fewer side effects.