Structural elucidation and anti-neuroinflammatory activity of Polygala tenuifolia polysaccharide.
- Zeng Z et al (2022).
- Int J Biol Macromol.
- PubMed:
- 36037912
Researchers isolated nine coumarins from the Sarcandra glabra plant, including a newly discovered pair of enantiomers. They tested all the compounds for acetylcholinesterase inhibiting activity and found that compound 3 showed the most significant effect with an IC value of 1.982±0.003 μM. The study confirms the potential therapeutic properties of coumarins and its ability to target Alzheimer's disease.
This study examines the differences in neuro-emotion between cognitively normal and cognitively impaired elderly individuals while viewing images of red fruit or without red fruit. The purpose is to determine which kind of images are more beneficial to individuals' neuro-emotions. Results may have implications for the use of images in therapy for cognitive impairment in the elderly.
A study found that Linn., an herb in Chinese medicine, contains compounds that exhibit anti-Alzheimer's disease (AD) activity. The main chemical components were identified through ultra-performance liquid chromatography-mass spectrometry and subsequently used for molecular docking. The transcriptome analysis revealed that leaves had relatively high expression of the anti-AD compounds, and transcription factors may be involved in their biosynthesis. The study provides insights into the biosynthetic pathway of anti-AD components and the regulation mechanism of active components and furthers the potential of Linn. as a treatment for AD.
Researchers isolated three alkaloids from Emilia sonchifolia plant, including a new compound called emililactam A. They separated two known compounds into their respective enantiomers, and their structures were confirmed using spectroscopic analysis and electronic circular dichroism calculations. In a cell culture study, emililactam A and two other compounds showed moderate neuroprotective effects against corticosterone-induced damage to PC12 cells.
Researchers conducted a systematic search to explore natural alternatives for the treatment of Alzheimer's disease (AD), as existing FDA-approved drugs have limitations. They analyzed randomized control trials and found that herbs like Gingko Biloba, Melissa Officinalis, Salvia officinalis, Ginseng, and saffron alone or in combination with curcumin, low-fat diet, NuAD-Trail, and soy lecithin showed significant positive effects on AD. Combining natural remedies with FDA-approved drugs showed more promising results than only using FDA-approved drugs. These findings suggest that herbal remedies could be effective in treating AD.