An insight into the neuroprotective effects and molecular targets of pomegranate (Punica granatum) against Alzheimer's disease.
- George N et al (2023).
- Nutr Neurosci.
- PubMed:
- 36125072
The neurodegenerative disease Alzheimer's currently has no complete cure, but flavones from L. have been found to promote synaptic plasticity and indirectly affect cholinergic neurotransmitters in a rat model. This study has potential implications for treating Alzheimer's disease.
Researchers investigated the immunopharmacological effects of pseudolycorine chloride (PLY), a constituent of L. var. Roem with antitumor and antiviral activities. They found that PLY significantly increased the production of cytokines and chemokines, indicating its potential in modulating the immune response. This study sheds light on the potential medical uses of PLY as an immunomodulator.
This article discusses the potential benefits of polyphenols in reducing age-related diseases, specifically focusing on their neuroprotective effects in Alzheimer's and Parkinson's disease. Studies show that some polyphenols play a role in maintaining neuronal homeostasis and improving cognitive function. However, inconsistencies in study design and interindividual variability impact their effectiveness. Pomegranate is highlighted as a promising treatment option, but further human clinical trials are needed.
Extracts from var. have been found to possess anticonvulsant properties, but their effectiveness in status epilepticus models has not been well studied. Researchers administered ethyl acetate and methanol extracts of the plant to rats before inducing seizures with kainic acid. Both extracts decreased the severity of seizures and prevented increased lipid peroxidation in various brain areas, kidneys, and liver. The methanol extract also increased the latency to seizure. These effects are likely due to the antioxidant properties of the extracts and their chemical constituents. The vehicle, olive oil, also showed anticonvulsant and antioxidant effects.
Researchers studied the potential for a plant extract to inhibit acetylcholinesterase, an important target for Alzheimer's disease treatment. They conducted in vitro testing and molecular docking studies, identifying certain compounds as potential inhibitors. Further simulations confirmed these potential hits. The plant extract and identified compounds show promise for further study in developing Alzheimer's treatments.
Alzheimer's disease (AD) is a neurodegenerative disease with complicated pathogenic processes including abnormal protein accumulation, oxidative stress, and inflammation. Cholinesterase inhibitors can somewhat alleviate AD symptoms, but new treatment options are needed.