Neuroscience Studies

Antiparkinsonian activity of Cucurbita pepo seeds along with possible underlying mechanism.

Researchers in Pakistan investigated the potential anti-Parkinson's activity of a methanolic extract of Cucurbita pepo (MECP) seeds. Using a rat model, they found that the extract improved motor functions. They also noted dose-dependent increases in catalase, superoxide dismutase, and glutathione levels, as well as decreases in malondialdehyde and nitrite levels. Molecular docking simulation suggested that certain phytoconstituents could bind to the active site of acetylcholine-esterase (AchE), a protein involved in the disease. Additionally, gene expression analysis revealed upregulation of alpha-synuclein and downregulation of TNF-alpha and IL-1beta. Finally, ADMET analysis predicted that selected phytochemicals exhibited moderately acceptable pharmacokinetics and toxicity. Overall, the results suggest that MECP could potentially ameliorate Parkinson's symptoms and may be a lead remedy for treatment.

Neuroscience Cucurbita pepo
Saleem U et al (2021).
Metab Brain Dis.
DOI:
10.1007/s11011-021-00707-6
PubMed:
33759084

Sex-Independent Cognition Improvement in Response to Kaempferol in the Model of Sporadic Alzheimer's Disease.

This study investigated the effect of the antioxidant Kaempferol (KMP) on a rat model of Alzheimer's disease (AD) induced by the injection of STZ. The researchers found that KMP improved spatial memory in both male and female rats, as well as increasing levels of certain antioxidants in the hippocampus. The study suggests that KMP may be beneficial in treating cognitive impairments associated with AD, and that these benefits are not influenced by gender.

Neuroscience Mespilus germanica
Babaei P, Eyvani K and Kouhestani S (2021).
Neurochem Res.
DOI:
10.1007/s11064-021-03289-y
PubMed:
33710535

Nephrotoxicity and neurotoxicity following star fruit (Averrhoa carambola) ingestion: a narrative review.

Star fruit toxicity can cause both kidney and neurological problems, especially in individuals with prior renal impairment. A review of ten case series and 28 case reports found that acute oxalate nephropathy with tubulointerstitial nephritis or tubular necrosis was common. Neurotoxicity manifestations ranged from hiccups to status epilepticus. The main substances causing nephrotoxicity and neurotoxicity were oxalate and caramboxin, which inhibits GABA binding and activates glutamatergic receptors. Early detection and renal replacement therapy can improve outcomes. Animal studies shed light on the underlying mechanisms of toxicity.

Neuroscience Averrhoa carambola
Yasawardene P et al (2021).
Trans R Soc Trop Med Hyg.
DOI:
10.1093/trstmh/trab026
PubMed:
33693950

Arctium lappa L. roots ameliorates cerebral ischemia through inhibiting neuronal apoptosis and suppressing AMPK/mTOR-mediated autophagy.

Arctium lappa L. roots have been shown to possess pharmacological benefits and protect neurons from injury in previous studies. This current study investigates whether the roots can prevent cerebral ischemia and the underlying mechanism. The results suggest that Arctium lappa L. root extract can reduce cerebral ischemic injury in rats and provides neuroprotection through multiple mechanisms. This study highlights the potential therapeutic value of Arctium lappa L. roots for treatment of cerebral ischemia.

CardiologyNeuroscience Arctium lappa
Yang Y et al (2021).
Phytomedicine.
DOI:
10.1016/j.phymed.2021.153526
PubMed:
33691269

Neuroprotective validation of pectin in T2DM-induced allodynia and hyperalgesia in diabetic peripheral neuropathic pain.

Researchers investigated whether pectin offers neuroprotective benefits against neuropathic pain in diabetic rodents. Results may inform potential treatment options for neuropathic pain in diabetic patients.

DiabetesNeurosciencePain Citrus sinensis
Srivastava R et al (2023).
Arch Physiol Biochem.
DOI:
10.1080/13813455.2021.1884725
PubMed:
33618606
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