Cerebroprotective effects of Moringa oleifera derivatives extracts against MCAO ischemic stroke: A systematic review and meta-analysis.

Researchers conducted a review and analysis on Moroccan olive extract's effects on ischemic stroke. They found it reduced infarct volume, malondialdehyde levels, and increased antioxidant enzymes, suggesting it may protect against stroke. Further studies are needed to confirm these promising results.

Cuschieri A, Camilleri E and Blundell R (2023).

Heliyon.

DOI:

10.1016/j.heliyon.2023.e16622

PubMed:

37303567

Antidepressant evaluation of Andrographis paniculata Nees extract and andrographolide in chronic unpredictable stress zebrafish model.

Researchers investigated the anti-depressive properties of Andrographis paniculata extract and andrographolide in a zebrafish model of chronic unpredictable stress. Both compounds showed a reduction in freezing duration compared to the stressed, untreated group, and andrographolide also decreased cortisol levels and increased activity. The study confirms the potential of zebrafish as a model for researching antidepressant drugs and suggests further investigation of andrographolide's cellular and molecular effects.

Aldurrah Z et al (2023).

Comp Biochem Physiol C Toxicol Pharmacol.

DOI:

10.1016/j.cbpc.2023.109678

PubMed:

37301417

11-Ethoxyviburtinal improves chronic restraint stress-induced anxiety-like behaviors in gender-specific mice via PI3K/Akt and E(2) /ERβ signaling pathways.

Lyu Y et al (2023).

Phytother Res.

DOI:

10.1002/ptr.7876

PubMed:

37300355

Annona muricate Extract Supplementation Contributes to Improve Aberrant Multi-Organ Energy Metabolism via Muscle-Brain Connectivity in Diabetic Mice.

This study investigated the effects of AM extract on the energy metabolism of T2DM mice. The extract increased insulin signaling in the skeletal muscle and hippocampus, and increased levels of myokines and neurotrophic factors. This suggests that AME may be a potential nutraceutical for improving energy metabolism and muscle-brain connectivity in T2DM.

Lee H, Kim SY and Lim Y (2023).

Nutrients.

DOI:

10.3390/nu15112559

PubMed:

37299522

Portulaca oleracea L. (purslane) improves the anti-inflammatory, antioxidant and autophagic actions of metformin in the hippocampus of diabetic demented rats.

Portulaca oleracea and Metformin improve cognitive function and reduce inflammation and oxidative stress in diabetic rats, suggesting their potential for addressing cognitive decline and hippocampal changes associated with diabetes. The AMPK pathway is identified as a key mediator, while Portulaca oleracea may have additional non-AMPK dependent actions.

Hassan SF et al (2023).

Fitoterapia.

DOI:

10.1016/j.fitote.2023.105566

PubMed:

37295752

Repurposing Non-pharmacological Interventions for Alzheimer's Diseases through Link Prediction on Biomedical Literature.

A study used a knowledge graph, ADInt, to predict new non-pharmaceutical interventions (NPI) for Alzheimer's Disease (AD) using computational drug repurposing. The graph included AD concepts and potential interventions, integrating dietary supplement domain knowledge graph and semantic relations. Machine learning models were compared to learn representation, and the R-GCN model outperformed others. Discovery patterns were used to generate mechanism pathways for high scoring predictions. The study discovered plausible mechanisms for photodynamic therapy and Choerospondias axillaris preventing AD. This study presents a novel methodology for discovering NPIs for AD and potentially other clinical problems.

Xiao Y et al (2023).

medRxiv.

DOI:

10.1101/2023.05.15.23290002

PubMed:

37292731

Shenqi formula delayed Alzheimer's disease-like symptoms by skn-1 pathway in Caernorhabditis elegans.

Zhi D et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.116741

PubMed:

37290734

Disease-Modifying Effects of Vincamine Supplementation in Drosophila and Human Cell Models of Parkinson's Disease Based on DJ-1 Deficiency.

Researchers found that a natural compound called vincamine showed promise in treating Parkinson's disease by improving motor ability in a fly model and reducing oxidative stress-induced death in human cells. Vincamine was shown to suppress PD-related symptoms and increased mitochondrial viability while decreasing apoptosis in human cells. The study also suggested that targeting voltage-gated sodium channels may be a promising avenue for treating PD.

Sanz FJ, Solana-Manrique C and Paricio N (2023).

ACS Chem Neurosci.

DOI:

10.1021/acschemneuro.3c00026

PubMed:

37289979