Rosmarinus officinalis and Mentha piperita Oils Supplementation Enhances Memory in a Rat Model of Scopolamine-Induced Alzheimer's Disease-like Condition.

Peppermint and rosemary oils were shown to have nootropic and anti-amnesic effects in rats with scopolamine-induced amnesia-like Alzheimer's disease (AD). The oils were orally administered to rats, and in the nootropic phase, both oils showed a decrease in latency times and memory errors. In the therapeutic phase, the oils enhanced memory processing. The hippocampus exhibited elevated BDNF levels, and immunohistochemistry findings showed increased hippocampal neurogenesis. Gas chromatography-mass spectrometry analysis of the oils revealed compounds with potential efficacy in memory and cognition. The combination of the two oils produced more anti-amnesic activity and had possible therapeutic activity for memory enhancement in AD patients.

Al-Tawarah NM et al (2023).

Nutrients.

DOI:

10.3390/nu15061547

PubMed:

36986277

Evaluation of the Antihypertensive Activity of Eggplant Acetylcholine and γ-Aminobutyric Acid in Spontaneously Hypertensive Rats.

Daily consumption of eggplant powder containing acetylcholine (ACh) can alleviate hypertension and improve mental status. A study was conducted to determine the effect of the compound γ-aminobutyric acid (GABA) on the antihypertensive effects of eggplant. The results showed that ACh is the main component associated with the antihypertensive effects of eggplant but GABA within eggplants has a minimal effect in this regard. Therefore, ACh is a more effective functional food constituent for lowering blood pressure compared to GABA.

Wang W et al (2023).

Molecules.

DOI:

10.3390/molecules28062835

PubMed:

36985807

Chemical Composition and In Vitro Antioxidant Activity and Anti-Acetylcholinesterase Activity of Essential Oils from Tadehagi triquetrum (L.) Ohashi.

Researchers analyzed the essential oils from (L.) Ohashi and identified 58 organic compounds, with palmitic acid, 1-Octen-3-ol, and Caryophyllene being the major ones. The essential oils had moderate antioxidant and anti-cholinesterase activity, indicating their potential use in these areas. The study provides new knowledge about the chemical and biological properties of (L.) Ohashi essential oils.

Song W et al (2023).

Molecules.

DOI:

10.3390/molecules28062734

PubMed:

36985706

Gastrodin and Gastrodigenin Improve Energy Metabolism Disorders and Mitochondrial Dysfunction to Antagonize Vascular Dementia.

This study explored the effects of two bioactive components of a traditional Chinese herbal medicine, GEB, on cognitive dysfunction in vascular dementia. The effectiveness of Gastrodin and Gastrodigenin was tested using various methods, including a water maze test and immunohistochemistry. The study showed that these components attenuated learning memory dysfunction and neuronal damage, reduced protein accumulation in the brain tissue and improved energy metabolism disorders in rats. This suggests that these components may provide neuroprotective effects by regulating energy metabolism and mitochondrial function in vascular dementia.

Wu S et al (2023).

Molecules.

DOI:

10.3390/molecules28062598

PubMed:

36985572

Chemical Characterization and Antioxidant, Antibacterial, Antiacetylcholinesterase and Antiproliferation Properties of Salvia fruticosa Miller Extracts.

Researchers examined the phytochemical composition and biological activities of extracts from . Four solvents of varying polarity were used for extraction, and the extracts were tested for their chemical composition, antioxidant, anti-Alzheimer, and antibacterial properties. The MeOH extract had strong antioxidant and antibacterial activity, while the EtOAc extract had strong anti-Alzheimer and anti-cancer activity. Ten previously unidentified chemical compounds were also discovered. This study highlights the potential of for therapeutic applications.

Dawra M et al (2023).

Molecules.

DOI:

10.3390/molecules28062429

PubMed:

36985401

Plant-Based Antioxidants for Prevention and Treatment of Neurodegenerative Diseases: Phytotherapeutic Potential of Laurus nobilis, Aronia melanocarpa, and Celastrol.

Pilipović K et al (2023).

Antioxidants (Basel).

DOI:

10.3390/antiox12030746

PubMed:

36978994

The effect of ginger (Zingiber officinale) supplementation on clinical, biochemical, and anthropometric parameters in patients with multiple sclerosis: a double-blind randomized controlled trial.

In a randomized, double-blind, placebo-controlled trial, ginger supplementation significantly reduced disability, physical and psychological quality of life, neurofilament light chain, interleukin-17, and neutrophil to lymphocyte ratio in patients with relapsing-remitting multiple sclerosis (MS), but did not affect body mass index or matrix metalloproteinase-9 levels. These findings suggest that ginger may be a promising adjuvant therapy for MS.

Foshati S et al (2023).

Food Funct.

DOI:

10.1039/d3fo00167a

PubMed:

36974730

Preclinical Evidence-based Neuroprotective Potential of Silibinin.

Silibinin, a natural product found in Silybum marianum, has been used for liver diseases and shows neuroprotective activities in animal studies. Studies suggest it alters several cellular and molecular signaling pathways, including BDNF and mTOR, exhibiting antioxidant effects. This review summarizes the pharmacology, side effects, and potential therapeutic effects of silibinin for neurodegenerative disorders. Silibinin may serve as a therapeutic alternative for neurodegenerative disorders and requires further preclinical and clinical research.

Kumar Singh N and Bhushan B (2023).

Curr Drug Res Rev.

DOI:

10.2174/2589977515666230327154800

PubMed:

36974407