Obesity Studies

A crossover randomized controlled trial examining the effects of black seed (Nigella sativa) supplementation on IL-1β, IL-6 and leptin, and insulin parameters in overweight and obese women.

This study examined the impact of Nigella sativa oil supplementation on overweight/obese women. The results suggest that NS oil may help manage inflammation and obesity by affecting blood mRNA expressions and levels of certain proteins.

ImmunologyObesity Nigella sativa
Razmpoosh E et al (2024).
BMC Complement Med Ther.
DOI:
10.1186/s12906-023-04226-y
PubMed:
38178093

Portulaca Oleracea L. (Purslane) Extract Protects Endothelial Function by Reducing Endoplasmic Reticulum Stress and Oxidative Stress through AMPK Activation in Diabetic Obese Mice.

Purslane, a food and drug, has various health benefits. This study found that it can improve endothelial function in diabetes by activating AMPK/eNOS signaling pathway, suggesting its potential in treating vascular complications.

DiabetesImmunologyObesity Portulaca oleracea
Miao L et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12122132
PubMed:
38136251

Thymoquinone mitigates obesity and diabetic parameters through regulation of major adipokines, key lipid metabolizing enzymes and AMPK/p-AMPK in diet-induced obese rats.

Thymoquinone (ThyQ) from seeds reduces obesity, lowers blood glucose and insulin, improves glucose tolerance, and enhances insulin sensitivity. It also reduces liver damage markers, increases adiponectin levels, and regulates gene expression. ThyQ may be a useful treatment for obesity and related conditions.

DiabetesObesity Nigella sativa
Ramineedu K et al (2024).
3 Biotech.
DOI:
10.1007/s13205-023-03847-x
PubMed:
38125651

Potential anti-obesity effects of two-graded doses of Iraqi Hibiscus tiliaceus leaves extract, alone and in combination with orlistat, on high-fat diet-induced obesity in male rats.

Study evaluated anti-obesity effect of Iraqi extract, alone or with orlistat, on high-fat diet-induced obesity in male rats. Extract reduced body weight, food intake, serum lipids, and liver enzymes. Extract shows potential as a therapeutic agent for obesity but more research needed for clinical efficacy and safety.

Obesity Hibiscus tiliaceus
Mohammed SK and Mutlag SH (2023).
J Med Life.
DOI:
10.25122/jml-2023-0140
PubMed:
38107717

Solanum aethiopicum L. from the Basilicata region as a source of specialized metabolites with promising anti-obesity effects: phytochemical characterization and in vivo investigation in high fat diet-fed mice.

Study shows extract from Basilicata scarlet eggplant inhibits enzyme activity, improves metabolism, reduces weight gain, inflammation, and enhances vascular function in obese mice, offering potential for obesity management.

ObesityPhytochemistry Solanum aethiopicum
Ponticelli M et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1306135
PubMed:
38074123

Thyme Extract Alleviates High-Fat Diet-Induced Obesity and Gut Dysfunction.

Thyme extract can help improve metabolic health in mice on a high-fat diet by reducing weight gain and body fat percentage, improving intestinal barrier function, and regulating serum biomarkers. Thyme also affects the levels of certain metabolites, showing promise in mitigating obesity and related gut conditions.

GastroenterologyObesity Thymus vulgaris
Lee YR et al (2023).
Nutrients.
DOI:
10.3390/nu15235007
PubMed:
38068865

Cydonia oblonga Miller fruit extract exerts an anti-obesity effect in 3T3-L1 adipocytes by activating the AMPK signaling pathway.

The study investigated the mechanism of how Miller fruit prevents obesity and promotes adipogenesis in preadipocytes. This information could help in developing new approaches for obesity prevention and treatment.

Obesity Cydonia oblonga
Lee HS et al (2023).
Nutr Res Pract.
DOI:
10.4162/nrp.2023.17.6.1043
PubMed:
38053822

Solanum melongena extract supplementation protected skeletal muscle and brain damage by regulation of BDNF/PGC1α/irisin pathway via brain function-related myokines in high-fat diet induced obese mice.

This study investigated the effects of SM extract (SME) on muscle and brain damage in obese mice. SME supplementation increased muscle-derived myokines and activated neurotrophic factors, potentially providing neuroprotection. SME may be used to prevent muscle and brain damage in obese patients.

NeuroscienceObesity Solanum melongena
Lee H, Kim SY and Lim Y (2023).
J Nutr Biochem.
DOI:
10.1016/j.jnutbio.2023.109537
PubMed:
38030047
1 9 10 11 20 32