Obesity Studies

Arctium lappa L. roots inhibit the intestinal inflammation of dietary obese rats through TLR4/NF-κB pathway.

Long-term consumption of L. root powder (ARP) leads to weight loss. ARP inhibits pro-inflammatory cytokines, down-regulates genes involved in TLR4 complexes, and reduces inflammation in the colons of obese rats. ARP has potential in improving intestinal health and treating obesity.

GastroenterologyImmunologyObesity Arctium lappa
Zeng F et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e21562
PubMed:
38027866

Effect of herbal extracts and Saroglitazar on high-fat diet-induced obesity, insulin resistance, dyslipidemia, and hepatic lipidome in C57BL/6J mice.

Researchers found that TC + PL extract reduced insulin resistance and liver weight in mice, while Saroglitazar reversed body weight and lipid level changes. These extracts hold promise for preventing obesity-related complications.

Obesity Glycyrrhiza glabraPiper longumTinospora cordifoliaWithania somnifera
Kumari D et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e22051
PubMed:
38027691

Carob Extract (Ceratonia siliqua L.): Effects on Dyslipidemia and Obesity in a High-Fat Diet-Fed Rat Model.

Researchers investigated the effects of carob extract and simvastatin on rats fed a high-cholesterol diet. They found that the combination reduced weight gain, lowered cholesterol levels, increased adiponectin, decreased leptin, and improved liver health. Carob may have potential in treating dyslipidemia and obesity.

Obesity Ceratonia siliqua
Rašković A et al (2023).
Pharmaceutics.
DOI:
10.3390/pharmaceutics15112611
PubMed:
38004588

Effects of an Unripe Avocado Extract on Glycaemic Control in Individuals with Obesity: A Double-Blinded, Parallel, Randomised Clinical Trial.

Researchers have found that unripe avocados contain mannoheptulose, a compound similar to calorie restriction. This finding could be significant for understanding potential benefits of caloric restriction and its effects on health.

Obesity Persea americana
Zhao L et al (2023).
Nutrients.
DOI:
10.3390/nu15224812
PubMed:
38004206

The Effect of Saffron Kozanis (Crocus sativus L.) Supplementation on Weight Management, Glycemic Markers and Lipid Profile in Adolescents with Obesity: A Double-Blinded Randomized Placebo-Controlled Trial.

Saffron supplementation can reduce weight, BMI, and waist circumference in obese prediabetic adolescents, although not as effectively as metformin. It can also improve lipid profiles and has potential as a nutraceutical option for weight management in adolescents with obesity and prediabetes.

DiabetesObesity Crocus sativus
Kotanidou EP et al (2023).
Children (Basel).
DOI:
10.3390/children10111814
PubMed:
38002905

In vitro Adipocyte Differentiation Inhibition and in vivo Effects on Lipid Metabolism in High-Fat Diet-Induced Obesity of Euphorbia humifusa.

The study found that extract from Willd has inhibitory effects on adipocyte differentiation and lipid metabolism. It reduced triglycerides and LDL-cholesterol in obese mice and inhibited lipogenesis in the liver. EHE could be a potential treatment for obesity and lipid metabolism issues.

Obesity Euphorbia humifusa
Lee SG and Kang H (2023).
J Microbiol Biotechnol.
DOI:
10.4014/jmb.2308.08004
PubMed:
37986586

The effect of calorie-restriction along with thylakoid membranes of spinach on the gut-brain Axis Pathway and oxidative stress biomarkers in obese women with polycystic ovary syndrome: a Randomized, Double-blind, placebo-controlled clinical trial.

In this study, researchers investigated the effects of spinach supplementation and a hypocaloric diet on women with polycystic ovary syndrome (PCOS). They found that this intervention improved gut health, neurotrophic factor levels, and oxidative stress in PCOS patients.

EndocrinologyGastroenterologyImmunologyNeuroscienceObesity Spinacia oleracea
Nikrad N et al (2023).
J Ovarian Res.
DOI:
10.1186/s13048-023-01288-x
PubMed:
37968684

Immature Persimmon (Diospyros kaki Thunb.) Ethanol Extract Ameliorates High-Fat Diet-Induced Obesity by Modulating Lipid Metabolism.

In this study, researchers found that immature persimmon extract (DKE) reduced weight gain and fat tissue in obese mice on a high-fat diet. It also improved lipid levels in the blood, gene expression in the liver, and inhibited enzymes related to fat synthesis. This suggests that DKE can help with obesity by modulating lipid metabolism.

Obesity Diospyros kaki
Yoon SA et al (2023).
Prev Nutr Food Sci.
DOI:
10.3746/pnf.2023.28.3.263
PubMed:
37842245
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