Proteomic analysis reveals that Polygonatum cyrtonema Hua polysaccharide ameliorates mice muscle atrophy in chemotherapy-induced cachexia.

In this study, researchers investigated the effects of Polygonatum cyrtonema Hua polysaccharide (PCP) on muscle atrophy caused by chemotherapy. They found that PCP, a compound derived from Polygonati Rhizoma herb, significantly reduced muscle loss and muscle fiber atrophy in mice. It also suppressed the decrease in immunoglobulin levels and the increase in pro-inflammatory factor interleukin-6 (IL-6). Proteomic analysis identified two primary targets of PCP: diacylglycerol kinase (DGKζ) and cathepsin L (CTSL). The study suggests that PCP regulates the autophagy-lysosome and ubiquitin-proteasome systems, providing a potential treatment for chemotherapy-induced muscle atrophy.

Tang XY et al (2023).

J Pharm Biomed Anal.

DOI:

10.1016/j.jpba.2023.115533

PubMed:

37336040

Diosgenin Attenuates Myocardial Cell Apoptosis Triggered by Oxidative Stress through Estrogen Receptor to Activate the PI3K/Akt and ERK Axes.

Chen MY et al (2023).

Am J Chin Med.

DOI:

10.1142/S0192415X23500556

PubMed:

37335210

Sleep-promoting activity of amylase-treated Ashwagandha (Withania somnifera L. Dunal) root extract via GABA receptors.

In this study, researchers evaluated the sleep-promoting effects of enzyme-treated Ashwagandha root extract (EA). The study found that EA increased sleep duration and improved sleep quality and quantity. It also effectively relieved caffeine-induced insomnia symptoms. The mechanism behind these effects was identified as the activation of the GABAergic system, which is involved in sleep regulation. This research suggests that EA could be used as a functional material to improve sleep deprivation.

Park CW et al (2023).

J Food Drug Anal.

DOI:

10.38212/2224-6614.3456

PubMed:

37335157

Biosynthesis and characterization of cobalt nanoparticles using combination of different plants and their antimicrobial activity.

Ali H et al (2023).

Biosci Rep.

DOI:

10.1042/BSR20230151

PubMed:

37334676

Centella asiatica (L.) Urban. Attenuates Cell Damage in Hydrogen Peroxide-Induced Oxidative Stress in Transgenic Murine Embryonic Stem Cell Line-Derived Neural-Like Cells: A Preliminary Study for Potential Treatment of Alzheimer's Disease.

Summary: Centella asiatica, also known as Gotu Kola, is popular in South East and South East Asian communities for its nutritional and medicinal advantages. In addition to its traditional uses for memory enhancement and wound healing, this plant's phytochemicals have been well-studied for their neuroprotective, neuroregenerative, and antioxidant properties. This research highlights the potential of Centella asiatica in promoting brain health and fighting against oxidative stress, making it a valuable plant for further investigation and potential therapeutic applications.

Mansor NI et al (2023).

J Alzheimers Dis.

DOI:

10.3233/JAD-221233

PubMed:

37334592

Identification and pathogenicity of multidrug-resistant Elizabethkingia miricola isolated from farmed American bullfrogs Rana catesbeiana in China with in vitro screening of herbal antimicrobial agents.

Liu F et al (2023).

J Aquat Anim Health.

DOI:

10.1002/aah.10185

PubMed:

37334434

Safety and efficacy of a feed additive consisting of an essential oil from the seeds of Myristica fragrans Houtt. (nutmeg oil) for all animal species (FEFANA asbl).

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) et al (2023).

EFSA J.

DOI:

10.2903/j.efsa.2023.8066

PubMed:

37333988

The Role of Asiatic Acid in Preventing Dental Pulp Inflammation: An in-vivo Study.

Nurhapsari A et al (2023).

Clin Cosmet Investig Dent.

DOI:

10.2147/CCIDE.S408158

PubMed:

37333763