Integrating Computational Methods in Network Pharmacology and In Silico Screening to Uncover Multi-targeting Phytochemicals against Aberrant Protein Glycosylation in Lung Cancer.

This work explores the potential of certain plant compounds to interact with cancer-associated glycoproteins. The researchers used computational methods and docking approaches to identify phytochemicals from selected plants with drug-like properties. They created a network to analyze the interactions between the compounds and glycoproteins. Several compounds, including α-pinene, cyanomaclurin, genistein, and quercetin, showed potential in binding to known cancer biomarkers. The researchers also performed cytotoxicity assays on plant extracts, finding that certain extracts had growth inhibitory activity against lung cancer cells. This research could help further understand the cytotoxic activities of these plant compounds.

Grijaldo SJB et al (2023).

ACS Omega.

DOI:

10.1021/acsomega.2c07542

PubMed:

37332828

Transcriptomics reveal the genetic coordination of early defense to Armillaria root rot (ARR) in Prunus spp.

Cai L et al (2023).

Front Plant Sci.

DOI:

10.3389/fpls.2023.1181153

PubMed:

37332708

MIK2 is a candidate gene of the S-locus for sporophytic self-incompatibility in chicory (Cichorium intybus, Asteraceae).

Palumbo F et al (2023).

Front Plant Sci.

DOI:

10.3389/fpls.2023.1204538

PubMed:

37332702

Genetic dissection of thousand-seed weight in linseed (Linum usitatissimum L.) using multi-locus genome-wide association study.

Saroha A et al (2023).

Front Plant Sci.

DOI:

10.3389/fpls.2023.1166728

PubMed:

37332700

Arum palaestinum delays hepatocellular carcinoma proliferation through the PI3K-AKT-mTOR signaling pathway and exhibits anticoagulant effects with antimicrobial properties.

Dwikat M et al (2023).

Front Pharmacol.

DOI:

10.3389/fphar.2023.1180262

PubMed:

37332348

Enzymatic degradation of azo dyes methylene blue and congo red with peroxidase purified from cauliflower using affinity chromatography technique: Kinetic study, optimization and metal binding activity.

Almaz Z and Agircelik FN (2023).

J Biosci Bioeng.

DOI:

10.1016/j.jbiosc.2023.05.011

PubMed:

37331844

Molecular characterization and functional analysis of glutathione S-transferase genes of pine wood nematode (Bursaphelenchus xylophilus) for avermectin.

Hao X et al (2023).

Comp Biochem Physiol C Toxicol Pharmacol.

DOI:

10.1016/j.cbpc.2023.109687

PubMed:

37331545

Synergistic impact of heat-ultrasound treatment on the properties and digestibility of Sagittaria sagittifolia L. starch-phenolic acid complexes.

Raza H et al (2023).

Int J Biol Macromol.

DOI:

10.1016/j.ijbiomac.2023.125457

PubMed:

37331532