Targeting autophagy to discover the Piper wallichii petroleum ether fraction exhibiting antiaging and anti-Alzheimer's disease effects in Caenorhabditis elegans.

Scientists studied the effects of natural medicines on autophagy and aging-related Alzheimer's disease using Caenorhabditis elegans (C. elegans). They found that the incidence of Alzheimer's disease is increasing along with decreased autophagy activity due to population aging. Multiple C. elegans models were used to evaluate autophagy and investigate the potential therapeutic effects of natural medicine in antiaging and anti-AD effects. This research provides valuable insights into understanding and treating aging-related diseases.

Zhu FD et al (2023).

Phytomedicine.

DOI:

10.1016/j.phymed.2023.154916

PubMed:

37327643

Melatonin enhances biomass, phenolic accumulation, and bioactivities of rosemary (Rosmarinus officinalis) in vitro shoots under UV-B stress.

Zhao Z et al (2023).

Physiol Plant.

DOI:

10.1111/ppl.13956

PubMed:

37327069

Use of iRNA in the post-transcriptional gene silencing of necrosis-inducing Phytophthora protein 1(NPP1) in Phytophthora cinnamomi.

Pascoal-Ferreira P et al (2023).

Mol Biol Rep.

DOI:

10.1007/s11033-023-08562-7

PubMed:

37326749

Spatial organization and dynamics of chromosomes and microtubules during barley mitosis.

Kaduchová K et al (2023).

Plant J.

DOI:

10.1111/tpj.16355

PubMed:

37326283

Network pharmacology and molecular docking-based identification of drug candidates and key targets of Allium sativum for colorectal cancer treatment.

Scientists are exploring alternative treatments for colorectal cancer (CRC) due to the limitations of current chemotherapeutics. In this study, researchers investigated the potential anti-CRC effects of a medicinal plant, (). They analyzed the plant's bioactive compounds and identified key targets for CRC treatment. Gene set enrichment analysis revealed the biological processes and pathways that could potentially be restored in CRC. Molecular docking studies identified beta-sitosterol and alpha-bisabolene as compounds with the highest binding affinity for the key targets. Further experimental studies are needed to validate these findings. This research has the potential to contribute to the development of more effective and targeted CRC treatments.

Olukunle OF, Omoboyede V and Chukwuemeka PO (2023).

J Biomol Struct Dyn.

DOI:

10.1080/07391102.2023.2220823

PubMed:

37325859

Essential oils for treating anxiety: a systematic review of randomized controlled trials and network meta-analysis.

Study compares efficacy of essential oils (EOs) for treating anxiety, aiming to clarify discrepancies in previous research. Researchers analyze results of multiple RCTs to provide insights into potential benefits of EOs.

Tan L et al (2023).

Front Public Health.

DOI:

10.3389/fpubh.2023.1144404

PubMed:

37325306

Vertigoheel promotes rodent cognitive performance in multiple memory tests.

A study was conducted to assess the potential cognitive benefits of VH-04, a drug that has been used for decades to treat vertigo. The researchers investigated its effects on memory and explored the biological mechanisms behind its activity. Cognitive impairment in older individuals and those with brain disorders can be debilitating, and current therapies only offer temporary improvement. This research aims to find new, safe, and effective therapeutics to reverse or delay cognitive impairment. By repurposing VH-04, a drug with a proven safety record, there is hope for developing a more successful treatment option.

Ott K et al (2023).

Front Neurosci.

DOI:

10.3389/fnins.2023.1183023

PubMed:

37325043

Effect on Ziziphus jujuba Mill. fruit powders embedded on physicochemical properties, biological activities, and rheologic quality of cake.

Elaloui M et al (2023).

Food Sci Nutr.

DOI:

10.1002/fsn3.3276

PubMed:

37324873