Glycosylated heterocyles emulsified with antifungal fraction of Moringa oleifera for potentiation of mycolytic activity.
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- Nat Prod Res.
- PubMed:
- 37309142
Bainiku-ekisu, a juice concentrate from Japanese Prunus mume, prevents hypertension and vascular remodeling caused by Angiotensin II. Further research on its cardiovascular benefits is needed.
Rosa roxburghii can improve insulin resistance in obese rats by reducing oxidative stress and increasing the expression of certain proteins and genes. This may be related to the PI3K/Akt2/GLUT4 signaling pathway.
Researchers have synthesized a derivative of ligustilide, a natural compound with anti-inflammatory properties, called ligusticum cycloprolactam (LIGc) to make it more stable. Using network pharmacological methods and experimental verification, they investigated the effects and mechanisms of ligustilide and LIGc on neuroinflammation. They identified four key targets of ligustilide that exert an anti-inflammatory effect, with the NF-κB signal pathway as the main signaling pathway. LIGc was found to downregulate the activation of the NF-κB signal pathway in BV2 cells induced by lipopolysaccharide and suppress the production of inflammatory cytokines, providing support for the development of anti-inflammatory drugs based on ligustilide or its derivatives.
Researchers found new lead compounds from the roots of the Rhus chinensis Mill plant that could be effective in treating heart failure by improving cardiac output and reducing apoptosis in zebrafish models.