Nucleoredoxin gene SINRX1 negatively regulates tomato immunity by activating SA signaling pathway.
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- Plant Physiol Biochem.
- PubMed:
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Sophora flavescens is a traditional treatment for NSCLC, but the active compounds are not well understood. Previous research suggests that common alkaloids in the plant are only effective at high concentrations. This study aims to identify the key antitumor alkaloids in S. flavescens. This research is important as it could lead to the discovery of novel compounds for more efficient NSCLC treatment options.
Researchers have successfully created a new form of Leukocyte phytohemagglutinin (PHA-L) through recombinant protein production. PHA-L, known for its antitumor and immunomodulatory effects, has potential as an antineoplastic agent in cancer treatment. However, previous acquisition methods have led to negative consequences such as toxicity and immunogenicity. The recombinant PHA-L protein demonstrated stronger antitumor effects and lower toxicity compared to natural PHA-L. This study provides a new strategy for developing drugs with immune regulation and direct antitumor activity.