10160.
Hypericum perforatum L. Nanoemulsion Mitigates Cisplatin-Induced Chemobrain via Reducing Neurobehavioral Alterations, Oxidative Stress, Neuroinflammation, and Apoptosis in Adult Rats.
A study investigated whether a medicinal plant, HP L., and its nanoemulsion could protect the brain from harmful effects of the chemotherapeutic agent, Cisplatin. HP.NE was tested on rats and showed that it improved motor activity and memory, increased antioxidant defense, reduced inflammation, and lowered brain levels of harmful molecules. HP.NE was found to be more effective at lessening oxidative stress, inflammation, and apoptosis in brain tissue than HP L. alone. These findings suggest that HP L. and its nanoemulsion could be useful in reducing neurotoxicity induced by chemotherapy.
Khalil HMA et al (2023).
Toxics.