Molecular Modes of Action of an Aqueous Nerium oleander Extract in Cancer Cells In Vitro and In Vivo.
- Rashan LJ et al (2023).
- Molecules.
- PubMed:
- 36838857
This study investigated the properties of the pericarp of maxim (PZM), a common Chinese spice and herbal medicine. Using various techniques, the study found that PZM contained certain chemical compounds that helped protect PC12 cells from oxidative damage induced by Aβ, a peptide linked to Alzheimer's disease. PZM treatment increased cell viability, reduced ROS levels, and downregulated caspase-3 and Bax mRNA expressions while upregulating Bcl-2 and Nrf2/HO-1 expressions. These findings suggest that PZM could be used as a potential protective agent against Aβ-induced neurotoxicity.