Herbal Products and Their Active Constituents Used Alone and in Combination with Antibiotics against Multidrug-Resistant Bacteria.
- Herman A and Herman AP (2023).
- Planta Med.
- DOI:
- 10.1055/a-1890-5559
- PubMed:
- 35995069
Researchers investigated thirty-nine natural compounds found in Ashwagandha, a medicinal plant. They found that Withanoside II is the most effective compound against COVID-19, and Withanoside III, IV, V, X, and XI also have favorable binding affinities. Molecular dynamics simulations confirmed the stable interactions between the compounds and the virus enzymes. The complexes formed between TMPRSS2-Withanolide Q and Mpro-Withanoside IV were the most stable. This research suggests that Ashwagandha compounds may have potential in treating COVID-19.
A study found that Linn., an herb in Chinese medicine, contains compounds that exhibit anti-Alzheimer's disease (AD) activity. The main chemical components were identified through ultra-performance liquid chromatography-mass spectrometry and subsequently used for molecular docking. The transcriptome analysis revealed that leaves had relatively high expression of the anti-AD compounds, and transcription factors may be involved in their biosynthesis. The study provides insights into the biosynthetic pathway of anti-AD components and the regulation mechanism of active components and furthers the potential of Linn. as a treatment for AD.