Novel resistances provide new avenues to manage Alternaria leaf spot (Alternaria brassicae) in canola (Brassica napus), mustard (B. juncea) and other Brassicaceae crops.
- Al-Lami HFD et al (2023).
- Plant Dis.
- PubMed:
- 35802017
DL-3-n-butylphthalide (NBP), derived from Apium graveolens seeds, has potential therapeutic effects for Parkinson's disease. Researchers established a rat model of the disease and found that NBP alleviated motor disturbance, prevented loss of dopaminergic neurons, reduced iron deposition in the substantia nigra and serum, and inhibited oxidative stress. The expression of iron metabolism-related proteins was altered by NBP treatment. These findings suggest that NBP mitigates Parkinson's disease by inhibiting iron deposition, oxidative stress, and ferroptosis in the substantia nigra.
Scientists investigated the potential use of Rubus idaeus leaf extracts as a safe alternative treatment for osteoarthritis symptoms, aiming to reduce reliance on nonsteroidal anti-inflammatory drugs with severe side effects.
In a study, ten bioactive compounds were identified in four plants and assessed for their cytotoxic and antiviral properties against SARS-CoV-2. Apigenin, catechin, apiin, and cinnamic acid showed potential as prophylactic and therapeutic candidates in preventing or treating COVID-19. Using in silico biology tools, the researchers found that these compounds displayed a greater binding affinity to the N-terminal and C-terminal RNA binding domains of SARS-CoV-2 nucleocapsid protein than remdesivir. Molecular dynamics simulation confirmed the stability of the ligand-protein complexes. These findings highlight the potential of naturally occurring compounds as novel drug candidates against SARS-CoV-2.
Researchers conducted a clinical trial to assess the pain-reducing effects of an herbal syrup as a complementary therapy after periodontal flap surgery.