Tossers studied binding between HCQ/SM and HSA, inducing conformational changes, with potential therapeutic relevance for COVID-19 due to strong interaction with virus proteases. Valuable insights for pharmaceutical and biological properties.
Prohibitin (PHB) plays a role in breast cancer, with altered expression linked to reduced overall survival. Moringin (MG) interacts with PHB and other proteins, inducing apoptosis and inhibiting cell growth and migration. MG modulates multiple cancer-related targets in breast cancer cells.
Researchers studied novel therapies that target specific pathways involved in secondary injury progression following TBI. Understanding these pathways may lead to improved treatments that can halt ongoing damage, reducing mortality and morbidity associated with TBI.
Marein from Coreopsis tinctoria Nutt can sensitize drug resistant cancer cells by inhibiting ABCG2 transporter, increasing drug accumulation, and binding to critical site F439. Potential implications for treating ABCG2-expressing tumors with chemotherapeutic drugs.
They studied a Chinese medicine extract from Semen Impatientis against prostate cancer in vivo and found it to be effective. This research could potentially lead to new treatments for prostate cancer.
Ganoderma lucidum contains compounds that may help manage diabetes and its complications by improving glucose metabolism and protecting pancreatic cells. More research needed for potential treatment with fewer side effects.