A network pharmacology method explores the molecular mechanism of Coptis chinensis for the treatment of Alzheimer's disease.

Network pharmacology predicted molecular mechanisms of Coptis chinensis in Alzheimer's treatment, revealing active ingredients, targets, and a drug-component-disease-target network. Main signaling pathways involved PI3K-Akt, AGE-RAGE, MAPK, HIF-1, TNF, and relaxin. Berberine demonstrated strong affinity, informing future clinical research.

Qian Q and Luo WL (2024).

Medicine (Baltimore).

DOI:

10.1097/MD.0000000000037103

PubMed:

38306514

Natural compound library screening to identify berberine as a treatment for rheumatoid arthritis.

Zhang L et al (2024).

Clin Rheumatol.

DOI:

10.1007/s10067-024-06871-1

PubMed:

38305937

Sonchus oleraceus L.: ethnomedical, phytochemical and pharmacological aspects.

Sonchus oleraceus is a beneficial plant with potential uses in treating various health issues, containing flavonoids and terpene lactones with antioxidant and antimicrobial properties. More research is required for its full potential.

Sánchez-Aguirre OA et al (2024).

Naunyn Schmiedebergs Arch Pharmacol.

DOI:

10.1007/s00210-024-02966-3

PubMed:

38305867

Neuroprotective Effects of Isolated Mangiferin from Swertia chirayita Leaves Regulating Oxidative Pathway on Streptozotocin-Induced Diabetic Neuropathy in Experimental Rats.

Researchers investigated the potential of Swertia chirayita, a plant with anti-inflammatory and antioxidant properties, to help with diabetic peripheral neuropathy (DPN), a complication of diabetes. Assessing oxidative stress's role in DPN is important for understanding and treating the condition.

Shivam and Gupta AK (2024).

Cent Nerv Syst Agents Med Chem.

DOI:

10.2174/0118715249255977231213053039

PubMed:

38305392

Hyperoside Inhibits RNF8-mediated Nuclear Translocation of β-catenin to Repress PD-L1 Expression and Prostate Cancer.

Hyperoside, found in Hypericum perforatum L., has potential anti-prostate cancer effects. This study examines its mechanisms in vitro and in vivo.

Chen J et al (2024).

Anticancer Agents Med Chem.

DOI:

10.2174/0118715206289246240110044931

PubMed:

38305391

Cynara Cardunculus Flavonoids-rich Fraction Alleviates Liver Injury in Mice Overconsumed Fructose Model.

Baali N et al (2024).

Recent Adv Food Nutr Agric.

DOI:

10.2174/012772574X275103231206050222

PubMed:

38305313

SSPH I, A Novel Anti-cancer Saponin, Inhibits EMT and Invasion and Migration of NSCLC by Suppressing MAPK/ERK1/2 and PI3K/AKT/mTOR Signaling Pathways.

SSPH I, a saponin found in Schizocapsa plantaginea, has anti-proliferative and antimetastatic effects on lung cancer. This research suggests potential for developing new treatments.

Zhou J et al (2024).

Recent Pat Anticancer Drug Discov.

DOI:

10.2174/0115748928283132240103073039

PubMed:

38305308

Antiviral Activity of Some Compounds of Gasteroid Mushrooms from Western Siberia.

A study found that extracts from three gasteroid fungi and cultivated mycelium showed strong antiviral activity against human and bird influenza. Extracts from two fungi were even more effective than the reference drug Tamiflu against bird influenza.

Makarevich EV et al (2024).

Int J Med Mushrooms.

DOI:

10.1615/IntJMedMushrooms.2023051031

PubMed:

38305261