Celastrol as an intestinal FXR inhibitor triggers tripolide-induced intestinal bleeding: Underlying mechanism of gastrointestinal injury induced by Tripterygium wilfordii.

Dai M et al (2023).

Phytomedicine.

DOI:

10.1016/j.phymed.2023.155054

PubMed:

37738906

Assessment of the hypoglycemic and anti-hemostasis effects of Paederia foetida (L.) in controlling diabetes and thrombophilia combining in vivo and computational analysis.

The study found that the methanolic extract of P. foetida leaves (PFLE) showed no toxicity, reduced blood sugar levels, increased body weight, and had anti-hemostasis effects. Deep learning predicted that Cleomiscosins, found in PFLE, have potential as drugs for managing diabetes and thrombophilia.

Ferdous J et al (2023).

Comput Biol Chem.

DOI:

10.1016/j.compbiolchem.2023.107954

PubMed:

37738820

Ca2+ - and Zn2+ -dependent nucleases co-participate in nuclear DNA degradation during programmed cell death in secretory cavity development in Citrus fruits.

Scientists analyzed the expression patterns of two nucleases (CrCAN and CrENDO1) during programmed cell death in Citrus fruits. They found that these nucleases work together to degrade nuclear DNA, providing evidence for ion-dependent nucleases in plant cell death.

Liang M et al (2023).

Tree Physiol.

DOI:

10.1093/treephys/tpad122

PubMed:

37738622

Plasmodiophora brassicae affects host gene expression by secreting the transcription factor-type effector PbZFE1.

Ando S et al (2024).

J Exp Bot.

DOI:

10.1093/jxb/erad377

PubMed:

37738570

Explore the anti-inflammation mechanism of safflower total flavonoids in the treatment of endometritis based on celluar transcriptomics.

Chen Y et al (2023).

J Pharm Pharmacol.

DOI:

10.1093/jpp/rgad082

PubMed:

37738315

Separation and purification of alkaloids and phenolic acids from Phellodendron chinense by pH-zone refining and online-storage inner-recycling counter-current chromatography.

This study separated and purified eight compounds from Phellodendron chinense using different chromatography techniques. The purified compounds include six alkaloids and two phenolic acids. Purity of the compounds was over 95.0%.

Zhu H et al (2023).

J Sep Sci.

DOI:

10.1002/jssc.202300497

PubMed:

37737621

The beneficial effects of the active components from Maclura tricuspidata fruits in the treatment of diabetes mellitus.

Zhang X et al (2023).

Nat Prod Res.

DOI:

10.1080/14786419.2023.2261067

PubMed:

37737157

GhIMP10D, an inositol monophosphates family gene, enhances ascorbic acid and antioxidant enzyme activities to confer alkaline tolerance in Gossypium hirsutum L.

Researchers conducted a study on cotton plants to analyze the expression and functions of key enzymes involved in ascorbic acid synthesis pathways. Understanding these pathways can help improve plant growth, development, and stress tolerance.

Fan Y et al (2023).

BMC Plant Biol.

DOI:

10.1186/s12870-023-04462-x

PubMed:

37736713