Tangeretin Attenuates Cerebral Ischemia-Reperfusion-Induced Neuronal Pyroptosis by Inhibiting AIM2 Inflammasome Activation via Regulating NRF2.

Tangeretin (found in Citrus reticulata peel) protects against cerebral ischemia and reperfusion (I/R) injury by inhibiting neuronal pyroptosis via the AIM2 inflammasome and regulating NRF2. TANG could be a potential therapy for I/R injury.

You G et al (2023).

Inflammation.

DOI:

10.1007/s10753-023-01900-8

PubMed:

37725272

Establishment of high-efficiency genome editing in white birch (Betula platyphylla Suk.).

Cheng D et al (2024).

Plant Biotechnol J.

DOI:

10.1111/pbi.14176

PubMed:

37723889

Neuroprotective potential of formononetin, a naturally occurring isoflavone phytoestrogen.

Formononetin, found in legumes and clovers, has shown potential in protecting neurons. It prevents neuronal damage, lowers tau phosphorylation, boosts neurogenesis, increases antioxidant expression, and inhibits inflammation and neurodegeneration. This review explores its biosynthesis and molecular pathways for neuroprotection.

Singh L et al (2023).

Chem Biol Drug Des.

DOI:

10.1111/cbdd.14353

PubMed:

37722967

Schweinfurthiamide, a new alkaloid isolated from the tuber roots of Asparagus flagellaris Baker (Liliaceae).

Kamdeu EN et al (2023).

Nat Prod Res.

DOI:

10.1080/14786419.2023.2257358

PubMed:

37722707

Genome-wide comprehensive characterization and Transcriptomic analysis of AP2/ERF gene family revealed its role in seed oil and ALA formation in Perilla (Perilla frutescens).

Researchers identified 212 AP2/ERF genes in perilla involved in oil accumulation. They found 36 AP2/ERFs correlated with 90 lipid metabolism genes, and identified 12 as important hub genes. Three AP2/ERFs (WRI, ABI4, and RAVI) were highlighted for their potential role in regulating oil accumulation, improving our understanding of oil accumulation in perilla and other oilseed crops.

Wu D et al (2023).

Gene.

DOI:

10.1016/j.gene.2023.147808

PubMed:

37722611

Saponins derived from Gynostemma pentaphyllum regulate triglyceride and cholesterol metabolism and the mechanisms: A review.

Gynostemma pentaphyllum is a plant that can be used for medicine and tea. It contains flavonoids and saponins and has various positive effects, including lowering cholesterol, fighting cancer, protecting the heart and liver, as well as offering neuroprotection, antidiabetic, and anti-inflammatory benefits.

Xie P et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117186

PubMed:

37722515

Fermentation of Ganoderma lucidum and Raphani Semen with a probiotic mixture attenuates cyclophosphamide-induced immunosuppression through microbiota-dependent or -independent regulation of intestinal mucosal barrier and immune responses.

Li Y et al (2023).

Phytomedicine.

DOI:

10.1016/j.phymed.2023.155082

PubMed:

37722243

Elucidation of anti-hyperglycemic activity of Psidium guajava L. leaves extract on streptozotocin induced neonatal diabetic Long-Evans rats.

The researchers investigated the antidiabetic properties of the Guava plant, which belongs to the Myrtaceae family. Understanding this can contribute to the development of potential treatments for diabetes.

Rahman MH et al (2023).

J Ayurveda Integr Med.

DOI:

10.1016/j.jaim.2023.100776

PubMed:

37722234