Genome-wide association study reveals novel SNPs and genes in Gossypium hirsutum underlying Aphis gossypii resistance.
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- PubMed:
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Glabridin, a compound found in Glycyrrhiza glabra, has shown potential in the treatment of Triple-negative breast cancer (TNBC). In a mouse model, glabridin enhanced the effectiveness of the front-line therapy, paclitaxel, by reducing tumor burden and inhibiting the formation of lung nodules. It also reversed the traits of hostile cancer cells and promoted apoptosis in tumor tissue. Furthermore, glabridin improved the pharmacokinetics of paclitaxel by slowing down its metabolism in the liver. With its dual role in enhancing anti-metastatic activity and limiting tumorigenesis, glabridin shows promise as a potential neoadjuvant therapy for paclitaxel chemoresistance and cancer recurrence. Further research is needed to fully explore its potential.