The aqueous root extract of Withania somnifera ameliorates LPS-induced inflammatory changes in the in vitro cell-based and mice models of inflammation.
- Sharma PK et al (2023).
- Front Pharmacol.
- PubMed:
- 37377934
Matrine, a compound extracted from a traditional Chinese herb, has been found to have anti-cancer properties in various types of cancer. However, its role in liver cancer has not been well understood. In this study, researchers investigated the effects of matrine on liver cancer cells. They found that matrine reduced cell viability and proliferation, while increasing cell apoptosis. Matrine also inhibited the Warburg effect, a metabolic characteristic of cancer cells. The researchers identified a specific molecular pathway involving circular RNA circROBO1, microRNA miR-130a-5p, and roundabout homolog 1 (ROBO1) that was influenced by matrine. In vivo experiments using a mouse model further supported the anti-cancer effects of matrine. This study provides scientific evidence supporting the potential use of matrine as an effective treatment for liver cancer.
Scientists modified pig leather with silver nanoparticles to create antimicrobial leather, which effectively kills bacteria, yeast, and mold without affecting its physical properties, making it suitable for hygienic shoes.
This study examined the impact of natural product extracts from P2Et and Anamú-SC plants on tumor cells, endothelial cells, and mesenchymal stem cells. The results revealed that the extracts selectively targeted tumor cells and were independent of intracellular ROS modulation. Additionally, the complexity of the extracts and the expression of Pgp influenced their interaction with chemotherapy drug doxorubicin. Interestingly, multicellular spheroids with MSC and EC showed modified effects on leukemia cell viability when treated with the extracts. This research provides insights into how botanical drugs can affect tumor microenvironments and contribute to understanding their pharmacodynamics.
Okra fruit extract shows significant anti-Alzheimer's activity in vitro and in vivo, improving symptoms and biomarkers in a rat model. Metabolomic and network pharmacology studies reveal connections between compounds in the extract and genes related to Alzheimer's disease. Promising dietary option for managing the disorder.
Oral cancer, a prevalent global disease, is influenced by genetic, immunological, and environmental factors. Smoking and alcohol consumption are the main risk factors associated with oral cancer. Understanding these factors is essential in preventing and treating this deadly disease.