Research explores dysbiosis in gut microbiota, genetic, immunological, and environmental factors in ulcerative colitis & Crohn's disease. Medicinal plants/compounds regulate NLRP3 inflammasome & reduce inflammation, offering treatment potential. Clinical validation and effective treatments development necessary.
Researchers have developed a new approach for treating breast cancer using a compound called piperine (PIP). PIP has shown promise as a chemotherapeutic agent, but its toxicity has limited its use. To overcome this, the researchers created a nanotechnology-based treatment by encapsulating PIP within an organic metal-organic framework (MOF) called MIL-100(Fe). They further enhanced the treatment by coating the MOFs with macrophage membranes (MM) to improve immune system evasion. Through laboratory experiments, the researchers confirmed the successful synthesis of MM@PIP@MIL-100(Fe) nanoparticles and demonstrated their increased cytotoxicity against breast cancer cells compared to free PIP. This innovative approach shows potential for effective breast cancer therapy and warrants further exploration and optimization.