Cancer Studies

Unraveling the Mechanism of Curculiginis Rhizoma in Suppressing Cisplatin Resistance in Non-Small Cell Lung Cancer: An Experimental Study.

Study investigates Curculiginis Rhizoma (CR) mixed with cisplatin to combat chemoresistance in NSCLC. Results show potential to enhance drug sensitivity by targeting ABC transporters. Crucial for improving chemotherapy outcomes in lung cancer.

Huang X et al (2024).
Onco Targets Ther.
PubMed:
38895133

Combination of Brucea javanica oil emulsion and Aidi injection associated with the long‑term survival of a patient with colon cancer and lung metastases post‑chemotherapy: A case report.

Two plant-derived products, BJOE and ADI, show promise in treating CRC with limited options, allowing a patient with resectable lung metastases to achieve >5 years progression-free survival. More research needed, but offers hope for future treatments.

Song J et al (2024).
Oncol Lett.
PubMed:
38895054

Molecular Aspects of Piperine in Signaling Pathways Associated with Inflammation in Head and Neck Cancer.

Piperine from black pepper shows potential as an anticancer agent for head and neck cancer. It inhibits cell growth, triggers apoptosis, and reduces inflammation and migration. It may be effective in regulating signaling pathways associated with cancer development.

Gusson-Zanetoni JP et al (2024).
Int J Mol Sci.
PubMed:
38891950

Exploring the immunological mechanism of Houttuynia cordata in the treatment of colorectal cancer through combined network pharmacology and experimental validation.

Study identified active components of Houttuynia cordata for CRC treatment. Quercetin and kaempferol target genes IL1B, MMP9, CXCL8, and IL6, inhibiting cell growth and promoting apoptosis. Potential for immunomodulation in CRC treatment.

Li Y et al (2024).
Naunyn Schmiedebergs Arch Pharmacol.
PubMed:
38888753

Exploring okra-derived compounds as prospective aromatase inhibitors: a computational study for enhanced breast cancer therapy.

Okra compounds like Quercetin 3-gentiobioside show potential as Aromatase inhibitors for estrogen receptor-positive breast cancer, with superior binding affinity and stability. Promising candidates for further preclinical studies.

Mallur DJ et al (2024).
J Biomol Struct Dyn.
PubMed:
38887049

Exploring the mechanism of Scleromitrion diffusum (Willd.) in treating lung cancer based on network pharmacology and experimental validation.

SDW components target 88 genes in lung cancer treatment, inhibiting cell proliferation via P I3K/Akt and MEK/ERK pathways. SDW may regulate apoptosis and proliferation in lung cancer therapy. Valuable insights into molecular mechanisms provided through network pharmacology, molecular docking, and experimental validation.

Huang S et al (2024).
Nat Prod Res.
PubMed:
38885333

Studies on Anticancer Effect of Methanolic Leaf Extract of Justicia gendarussa on Lung Cancer Cell Line.

Study tested methanolic extract for anticancer properties on lung cancer cells. Implications for potential cancer treatment.

Lavanya R and Vimal S (2024).
J Pharm Bioallied Sci.
PubMed:
38882728